Withdrawn/Discontinued Ion Channel Drugs

Sometimes, drugs can be discontinued or withdrawn from the market. There could be different reasons for this, including safety issues, regulatory issues, lack of efficiency or commercial failure. Here is the list of withdrawn/discontinued ion channel drugs.

NameBrand namesMechanism of actionIndicationTypeStatusYear of Approval/WithdrawalCompanyNotes
AcetohexamideDymelorKir6.2 inhibitorDiabetes mellitus type 2 Small moleculeWithdrawn in the US1964/Lilly
AlpidemGABA-A agonistAnxietySmall moleculeWithdrawn1991 (France)/1994Synthélabo
BepridilVascorCav1.x blockerHypertension, chronic stable anginaSmall moleculeWithdrawn1990/2004
ButambenAlvogil Cav inhibitorSkin irritation, chronic painSmall moleculeWithdrawn
CronidipineCav blockerHypertensionSmall moleculeDiscontinuedGroupe Fournier
EncainideEnkaidNav blockerVentricular premature beatsSmall moleculeWithdrawn/1991
GaboxadolGABA-A antagonistInsomniaSmall MoleculeDiscontinuedLundbeck and Merck
HalazepamPaxipam, Alapryl, PacinoneGABAA potentiatorAnxietySmall moleculeWithdrawn in the US1981/2009Schering-Plough
LindaneScabeneGABA-A (Sarcoptes scabiei) negative modulatorInfestation by Sarcoptes scabiei, PediculosisSmall moleculeWithdrawn1974/
LinopirdineKCNQ blockersAlzheimer's diseaseSmall moleculeDiscontinued
MephenytoinMesantoinNav blockerEpilepsySmall moleculeWithdrawn1946/Novartis
MibefradilPosicorCav1.x inhibitor, Cav3.x inhibitor Hypertension, angina Small moleculeWithdrawn1997/1998Roche
MoracizineEthmozineNav1.5 blockerVentricular arrhythmiaSmall moleculeWithdrawn1990 FDA/2007
PF-05089771Nav1.7 inhibitorPainful diabetic peripheral neuropathySmall MoleculeDiscontinued2015PfizerFailed phase II
RetigabineTrobalt, PotigaKv7.2-Kv7.5 activatorEpilepsySmall moleculeDiscontinued2011/2017GSK
RG-6029GDC-0310Nav1.7 inhibitorPainSmall MoleculeDiscontinued2018Roche/Genentech/Xenon
SenicapocKCa3.1 (Gardos channel) blockerHereditary xerocytosisSmall MoleculeSpringWorks TherapeuticsRepurposed
SenicapocKCa3.1 (Gardos channel) blockerSickle cell disease and asthmaSmall MoleculeDiscontinuedIcagen
TriazolamHalcionGABA-A positive modulatorInsomniaSmall moleculeWithdrawn in the UK1982/
UnoprostoneResculaBK and CLC-2 activatorOcular hypertension, open-angle glaucomaSmall MoleculeDiscontinued in the US2000 FDA/ 2015 Sucampo Pharmaceuticals
TV-45070Nav1.7 inhibitorPost-herpetic neuralgiaSmall MoleculeDiscontinued2017Teva/XenonFailed phase II
VixotrigineBIIB074Nav1.7 inhibitorPainful lumbosacral radiculopathy Small MoleculeDiscontinued2018BiogenFailed phase II
Z160MK-6721, NMED-160Cav2.2 antagonistChronic painSmall moleculeDiscontinuedNeuromed, Zalicus
ZoxazolamineZoxineKCa activatorSpasmSmall moleculeWithdrawn1955/1961
VX-128
NaV1.8 inhibitor
Pain
Small moleculeDiscontinued2018Vertex Pharmaceuticals
VX-961
NaV1.8 inhibitor
Pain
Small moleculeDiscontinued2020Vertex Pharmaceuticals