Cambridge Ion Channel Forum

Metrion Biosciences and AstraZeneca are delighted to be co-hosting the 2023 Cambridge Ion Channel Forum at the Babraham Research Campus Conference Centre on the afternoon of Wednesday 10th May 2023. You will have the opportunity to enjoy a series of presentations from esteemed ion channel scientists, promote your research during the dedicated poster session and network with other ion channel enthusiasts.

Illuminating new roles for Nav1.1 in somatosensory signaling and behavior – Dr Theanne Griffith, UC Davis

Peripherally expressed NaV1.1 is critical for sensory proprioceptive signaling and motor coordination.

Cardiac Safety Symposium 2023

At the Cardiac Safety Symposium you can learn about newest insights on current challenges in safety pharmacology, cardiac physiology, electrophysiology and contractility assessments of stem cell-derived and native cardiomyocytes.

Uncovering the secret life of membrane proteins with mechanistic genetic screens – Willow Coyote-Maestas, University of California San Francisco

Regulation of cardiac Nav1.5 channels by phosphorylation – Dr Céline Marionneau, University of Nantes

Phosphorylation of the cardiac NaV1.5 channel pore-forming subunit is extensive and critical in modulating channel expression and function, yet the regulation of NaV1.5 by phosphorylation of its accessory proteins remains elusive.

Inward cardiac sodium current in health and disease – Prof. Silvia Priori, University of Pavia

Silvia Priori's lab studies mechanisms of genetic arrhythmias.

7th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets

This symposium, the 7th in an ongoing series, will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.

Novel Patch Clamp to Advance Pain Research

In this webinar, attendees will gain insight into the realm of automated patch clamp assays, exploring the mechanisms of pain.

Cardiac ephaptic coupling and interactions between sodium channels: myths or realities? – Prof. Jan Kucera, University of Bern

Ephaptic interactions mediated by extracellular potentials might contribute to cardiac conduction when gap junctional coupling is reduced, but this mechanism is still controversial.

Biophysical Society Annual Meeting

The Biophysical Society annual meetings are the largest annual gathering of biophysicists around the world.

Acid-activated Cl-Channel ASOR/TMEM206: A Previously Enigmatic Channel with Roles in Endosomes – Dr. Thomas Jentsch, Max Delbrück Center for Molecular Medicine, Berlin

The acid-sensitive chloride ion channel ASOR is found in almost all our cells. ASOR plays a role in acid-induced cell death, but a role in intracellular processes, for example in the transport of vesicles, is now coming to the fore.

Dravet syndrome mouse models for novel gene therapy development – Dr Moran Rubinstein, Tel Aviv University

Dravet syndrome is severe childhood-onset epilepsy, caused by loss of function mutations in the SCN1A gene. Novel therapies aim to restore SCN1A expression in order to address all disease manifestations.

Ion channels and cancer meeting 2022

This meeting will be dedicated to exploring ion channel regulation from molecular biophysics to physiology and clinical applications in cancer biology. Meeting will also include one ECS session: "Calcium signaling in cancer".

Voltage-gated sodium channels and cancer – Dr William Brackenbury, University of York

Repurposing VGSC-inhibiting medications to cancer may hold promise for reducing metastasis.

Membrane proteins and mechanisms of disrupted cellular homeostasis – Anna Greka, Harvard Medical School, USA

Anna Greka leads a program focused on dissecting fundamental mechanisms of disrupted cellular homeostasis in genetically-defined kidney, metabolic and degenerative diseases...

Understanding the function of sodium channel accessory proteins using pain-causing toxins – Prof Irina Vetter, University of Queensland

The pharmacological activity of pain-causing toxins can provide critical insights into the molecular mechanisms underpinning sensory neuron function and pain...

Gain-of-function mutations in Nav1.6 and epileptic seizures – Dr Manoj Patel, University of Virginia.

Many de novo missense mutations of SCN8A, the gene that encodes for Nav1.6, have been identified and patients have seizure onset between birth and 12 months of age...