Worldwide-Sodium-Channel-Seminars

Past Events

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Dravet syndrome is severe childhood-onset epilepsy, caused by loss of function mutations in the SCN1A gene. Novel therapies aim to restore SCN1A expression in order to address all disease manifestations.

Careers

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Source: University of East Anglia

neuro

Research

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Source: Harvard John A. Paulson School of Engineering and Applied Sciences

A new method for modulating neural activity using optogenetic polymerization and assembly of electroactive polymers on specified cellular membranes.

Careers

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Source: Dundalk Institute of Technology

Image by NomeVisualizzato from Pixabay

Research

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Source: Children's Hospital of Philadelphia

The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disorder.

Lille, France

Past Events

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This meeting will be dedicated to exploring ion channel regulation from molecular biophysics to physiology and clinical applications in cancer biology. Meeting will also include one ECS session: "Calcium signaling in cancer".

Worldwide-Sodium-Channel-Seminars

Past Events

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Repurposing VGSC-inhibiting medications to cancer may hold promise for reducing metastasis.

AnnaGrekaWebinar-2022 - Life Sciences Switzerland

Past Events

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Anna Greka leads a program focused on dissecting fundamental mechanisms of disrupted cellular homeostasis in genetically-defined kidney, metabolic and degenerative diseases...

Worldwide-Sodium-Channel-Seminars

Past Events

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The pharmacological activity of pain-causing toxins can provide critical insights into the molecular mechanisms underpinning sensory neuron function and pain...

urine test

Research

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Source: Aarhus University

Challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.

Careers

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Source: Metrion

Careers

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Source: Metrion Biosciences

Uncategorized

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Source: jobRxiv

Careers

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Source: Nature careers

Careers

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Source: Nanion

Careers

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Source: Nanion

Metrion Biosciences

Past Events

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Many de novo missense mutations of SCN8A, the gene that encodes for Nav1.6, have been identified and patients have seizure onset between birth and 12 months of age...

San Diego

Events

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The Biophysical Society annual meetings are the largest annual gathering of biophysicists around the world.

Building

Events

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This symposium, the 7th in an ongoing series, will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.

cancer-ion-ch

Events

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This will be an inaugural scientific event, providing a platform for the sharing and critical analysis of the latest cutting-edge research findings, most recent movements and latest upgrades in the new field of Ion Channels in Cancer.

Events

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Metrion Biosciences and AstraZeneca are delighted to be co-hosting the 2023 Cambridge Ion Channel Forum at the Babraham Research Campus Conference Centre on the afternoon of Wednesday 10th May 2023. You will have the opportunity to enjoy a series of presentations from esteemed ion channel scientists, promote your research during the dedicated poster session and network with other ion channel enthusiasts.

Events

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The program will address the rapidly moving research on receptor-regulated calcium signaling and the critical questions that are key to establishing future therapies for cardiovascular, airway, gut, liver, immunoinflammatory, metabolic and neurological disorders.

Events

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This workshop aims to cover all aspects of NALCN research, including involvement of patient families & physicians, and research highlighting in vivo studies, along with NALCN molecular structure and function.

sgp2023

Events

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This 2023 SGP Meeting will be focused on the topic of pain and will offer an excellent opportunity for participants to interact with leading scientists tackling impactful questions in the pain field, from the biophysical to behavioral level.

cancer cells

Research

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Source: Imperial College London

The high-throughout, cellular-resolution imaging data indicate that Vm fluctuates dynamically in subpopulations of highly aggressive breast cancer cell lines.

heart

Research

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Source: Weill Cornell Medicine

Anionic lipids unlock the gates of select ion channels in the pacemaker family

Research

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Source: University College London

UCL researchers developed a gene therapy strategy that self-selects pathologically overactive neurons and down-regulates their excitability via controlled expression of Kv1.1.

cancer-cells

Research

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Source: Johns Hopkins Medicine

Elevated viscosity counterintuitively increases the motility of various cell types in a TRPV4-dependent manner.

sleep

Research

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Source: Johns Hopkins Medicine

TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.

Events

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World-renowned speakers, pioneers in the field of channelopathies, will present their latest discoveries.

lab mouse - Image by Tibor Janosi Mozes from Pixabay

Research

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Source: Johns Hopkins Medicine

Researchers discovered that blocking the TRPC6 channel in genetically modified mice with severe or moderate Duchenne muscular dystrophy substantially improves their skeletal and cardiac muscle function, bone deformities and survival.

A girl listening to music - Photo by Tirachard Kumtanom on Pexels

Research

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Source: University of Colorado

cAMP and voltage modulate rat auditory mechanotransduction by decreasing the stiffness of gating springs.

car park

Research

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Source: MIT

While the biosynthesis of the voltage-gated Ca2+ channels does not play a major role in regulating their abundance at presynaptic active zones, both trafficking and recycling at active zones are important regulatory steps.

chemist - Image by Michal Jarmoluk from Pixabay

Research

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Source: Tokyo Institute of Technology

Inspired by mechanosensitive potassium channels found in nature, researchers have developed the first synthetic mechanosensitive potassium channel.

Cat, itch - Photo by Fox on Pexels

Research

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Source: Fierce Biotech

Researchers showed that the Piezo2 channels in Merkel cells are responsible for the itch triggered by mechanical stimulation in dry skin.

flashlight

Research

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Source: The University of Texas Health Science Center at Houston

Researcher have discovered two naturally occurring channelrhodopsins enabling optogenetic control of K+ gradients, which is promising for the study and potential treatment of potassium channelopathies such as epilepsy, Parkinson’s disease and long-QT syndrome and other cardiac arrhythmias.

Kv4

Research

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Source: St. Jude Children’s Research Hospital

New findings elucidate mechanisms of closed-state inactivation and voltage-dependent activation of the KV4 channel.

Caraway Therapeutics

Industry

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Source: Caraway Therapeutics

money

Industry

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Source: NMD Pharma

heart - Photo by Robina Weermeijer on Unsplash

Research

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Source: Fierce Biotech

Scientists demonstrated that prokaryotic sodium channels can be directly, specifically, and stably expressed in cardiomyocytes through viral gene delivery to augment tissue excitability and conduction.

Icagen - neuron

Industry

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Source: Ligand Pharmaceuticals

neurons

Research

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Source: MIT

Human neurons have fewer ion channels compared to the neurons of other mammals.

Metrion Biosciences

Industry

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Source: Metrion Biosciences

Nanion Technologies

Industry

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Source: Nanion Technologies

businessman

Industry

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Source: Metrion Biosciences

businessman - Photo by Adetola Afolabi on Unsplash

Industry

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Source: Metrion Biosciences

coronavirus - Photo by Fusion Medical Animation on Unsplash

Research

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Source: MIT

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity.

Ardem Patapoutian and David Julius

Research

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Source: The Kavli Prize

The Norwegian Academy of Science and Letters has decided to award the 2020 Kavli Prize in Neuroscience to David Julius and Ardem Patapoutian “for their transformative discovery of receptors for temperature and pressure.”