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SEP
1
Electrophysiology & Imaging Techniques for Cell Physiology
Virtual Workshop
SEP
2
New Roles for Ion Channels and Transporters in Health and Disease
Online Symposium
SEP
7
SEP
16
SEP
22
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Fundamentals
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What are ion channels?
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Nobel Prizes
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History of ion channels
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Why we should care about ion channels
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Membrane transport
Every cell possesses a variety of sophisticated membrane transport systems allowing for control of the intracellular environment.
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History of ion channels
Before the 1660s the Theory of Animal Spirits dominated thinking regarding the function of the nervous system. “Animal spirits” (originating in the brain) were believed to control movements of the body by flowing through the nerves into the muscles.
Interviews
Articles Pubmed
- Electrophysiological modeling of the effect of potassium channel blockers on the distribution of stimulation wave in the human gastric wall cells. J Biomech. 2021 Aug 4.
- The role of voltage-gated chloride channels in the epileptogenesis of temporal lobe epilepsy. EBioMedicine. 2021 Aug 11.
- Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK. Neuron. 2021 Aug 11
- RyR-mediated Ca2+ release elicited by neuronal activity induces nuclear Ca2+ signals, CREB phosphorylation, and Npas4/RyR2 expression. Proc Natl Acad Sci U S A. 2021 Aug 17.
- Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK. Neuron. 2021 Aug 11
preprints bioRxiv
- The diazepam binding inhibitor’s modulation of the GABA-A receptor is subunit-dependent
- Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology
- Structural modeling of the hERG potassium channel and associated drug interactions
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
- Kv4.3 channel downregulation mediates chronic post-lesional pacemaker acceleration in surviving dopamine substantia nigra neurons
- Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population
PATENTS GOOGle patents
- The diazepam binding inhibitor’s modulation of the GABA-A receptor is subunit-dependent
- Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology
- Structural modeling of the hERG potassium channel and associated drug interactions
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
- Kv4.3 channel downregulation mediates chronic post-lesional pacemaker acceleration in surviving dopamine substantia nigra neurons
- Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population
CLINICAL TRIALS ClinicalTrials
- The diazepam binding inhibitor’s modulation of the GABA-A receptor is subunit-dependent
- Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology
- Structural modeling of the hERG potassium channel and associated drug interactions
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
- Kv4.3 channel downregulation mediates chronic post-lesional pacemaker acceleration in surviving dopamine substantia nigra neurons
- Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population
Ion Channels on Social media
- Electrophysiological modeling of the effect of potassium channel blockers on the distribution of stimulation wave in the human gastric wall cells. J Biomech. 2021 Aug 4.
- The role of voltage-gated chloride channels in the epileptogenesis of temporal lobe epilepsy. EBioMedicine. 2021 Aug 11.
- Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK. Neuron. 2021 Aug 11
- RyR-mediated Ca2+ release elicited by neuronal activity induces nuclear Ca2+ signals, CREB phosphorylation, and Npas4/RyR2 expression. Proc Natl Acad Sci U S A. 2021 Aug 17.
- Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK. Neuron. 2021 Aug 11
- The diazepam binding inhibitor’s modulation of the GABA-A receptor is subunit-dependent
- Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology
- Structural modeling of the hERG potassium channel and associated drug interactions
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
- Kv4.3 channel downregulation mediates chronic post-lesional pacemaker acceleration in surviving dopamine substantia nigra neurons
- Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population
- The diazepam binding inhibitor’s modulation of the GABA-A receptor is subunit-dependent
- Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology
- Structural modeling of the hERG potassium channel and associated drug interactions
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
- Kv4.3 channel downregulation mediates chronic post-lesional pacemaker acceleration in surviving dopamine substantia nigra neurons
- Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population
CLINICAL TRIALS ClinicalTrials
- The diazepam binding inhibitor’s modulation of the GABA-A receptor is subunit-dependent
- Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology
- Structural modeling of the hERG potassium channel and associated drug interactions
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
- Kv4.3 channel downregulation mediates chronic post-lesional pacemaker acceleration in surviving dopamine substantia nigra neurons
- Variant landscape of the RYR1 gene based on whole genome sequencing of the Singaporean population
Ion Channels on Twitter
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