Nocion Therapeutics, a biopharmaceutical company developing novel small molecule charged sodium channel blockers (nocions), for the treatment of cough, itch, and pain, announced it started a Phase 1 study of its novel inhaled cough therapy, NOC-100.
NOC-100, is an inhaled formulation of NTX-1175 (Nocion’s lead small molecule charged sodium channel blocker being developed for cough). NTX-1175 selectively affects actively firing inflamed nociceptors by entering those nociceptors through large-pore channels and inhibiting sodium channels. Previously, NTX-1175 has shown excellent efficacy in preclinical models of cough.
NOC-100 has the potential to treat both chronic and acute cough, and thus it could be useful for suppressing cough in patients with COVID-19.
As Nocion evolved to the clinical development stage, they strengthened their leadership team by hiring Christopher Silber, M.D. as Chief Medical Officer and appointing Michael Higgins to the Board of Directors.
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