Kineta Chronic Pain, a subsidiary of Kineta, announced that the company will extend and expand its research collaboration with Genentech to advance a first-in-class α9/α10 nAchR antagonist, KCP506, for the treatment of chronic pain into Phase 1 clinical trials. Kineta will also receive an undisclosed payment from Genentech to extend the research collaboration.
Kineta initially established a research collaboration and option agreement with Genentech in April 2018. Under the terms of the agreement, Genentech has an option to license assets developed during the research collaboration.
KCP506 is a first-in-class α9α10 nAChR antagonist in development for the treatment of chronic neuropathic pain. Kineta recently received Clinical Trial Application approval from the Netherlands to initiate Phase 1 trials of KCP506. A single ascending dose and multiple ascending dose study will be conducted in healthy subjects to evaluate the safety, tolerability, and pharmacokinetics of KCP506 and will commence in Q4 2020.
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