I think that ion channels are the most important single class of proteins that exist in the human body or any body for that matter.
Ion channels are involved in every thought, every perception, every movement, every heartbeat.
No cell could exist without ion channels.
Ion channels are so critical, they control so much of our physiology, so much of what makes us ‘us’.
If you really want to get deep you could even argue that ion channels are the molecular source of the soul.
I have ion channels, therefore I think, therefore I am.
Ion channels rock!
Keep Calm and Carry iOns.
The sewing machine is effectively an electrophysiology rig.
I think of a patch clamp rig like a piano. Anyone with enough money can buy a piano, but it takes months or years to learn how to PLAY the piano.
We think of Automated Patch Clamp like an iPhone. It might not be cheap to buy one, but when you have it, it doesn’t require much training and it will make your life a whole lot easier.
Gandalf was an ion channel. He told the Balrog it couldn’t pass.
What is an ion channel but a boring hole in the membrane? Transporters are the way to go!
To use a car analogy: transporters are the slow, sluggish, gas-guzzling SUVs that no one should own; whereas ion channels are the classy, chic, sleek & speedy E-type Jaguar that everyone lusts after.
Transporters are slow contortionists while ion channels are fast and subtly dancers.
Every facade of the human condition is an ion communicating its desires through a channel.
Ion channels are the most boring topic in the world.
I swear ligand-gated ion channels will be the death of me. So boring.
Whether gated by voltage or ligand, ion channels are crucial in cellular regulation.
Ion channels are like the doors and windows of the cell onto the world.
Ephys room with 4 rigs. Multi-lingual swearing all day long.
Patch clampers are all about instant gratification. We sit down and we know if it’s going to work or not in 20 minutes.
The sensitivity of ion channels makes us sensitive.
To fix the rig… you have to become the rig.