| Name | Mechanism of action | Indication | Year of Approval | Type of medicine | Subtype of medicine | Note |
|---|---|---|---|---|---|---|
| Amiloride | ENaC inhibitor | Hypertensive disorder, edema, hypokalemia | 1981 | Diuretics | ||
| Amiodarone | Kv11.1 blocker | Ventricular fibrillation, life-threatening ventricular tachycardia | 1961 | Cardiovascular medicines | Antiarrhythmic medicines | Complementary List |
| Amlodipine | Cav1.x inhibitor | Hypertension, vasospastic angina, angina pectoris | 1992 | Cardiovascular medicines | Antihypertensive medicines | |
| Atracurium | Chrn abd antagonist | General anaesthesia, muscle relaxation | 1983 FDA | Mucsle relaxants (peripherally acting) and cholinesterase inhibitors | ||
| Bupivacaine | Nav inhibitor | Local anesthesia | 1972 FDA | Anaesthetics, preoperative medicines and medical gases | Local anaesthetics | |
| Carbamazepine | Nav1.5 blocker | Epilepsy, Lennox-Gastaut syndrome, bipolar disorder | 1968 | Anticonvulsants/Antiepileptics | ||
| Medicines for mental and behavioural disorders | Medicines used in bipolar disorders | |||||
| Diazepam | GABA-A potentiator | Anxiety, alcohol withdrawal syndrome, spasticity, epilepsy | 1963 FDA | Medicines for pain and paliative care | Medicines for other common symptoms in palliative care | |
| Anticonvulsants/Antiepileptics | ||||||
| Medicines for mental and behavioural disorders | Medicines for anxiety disorders | |||||
| Diazoxide | Kir6.2 activator | Hypertensive emergencies, hyperinsulinism | 1973 | Medicines for endocrine disorders | Medicines for hypoglycaemia | Complementary List |
| Ethosuximide | Cav3.1 inhibitor | Absence seizures | 1960 | Anticonvulsants/Antiepileptics | Complementary List | |
| Gliclazide | Kir6.2 inhibitor | Diabetes mellitus type 2 | 1972 | Medicines for endocrine disorders | Medicines for diabetes | Oral hypoglycaemic agents |
| Halothane | GABA-A agonist, GluA1 inhibitor, GLYRA1 agonist | General anesthesia | 1958 FDA | Anaesthetics, preoperative medicines and medical gases | General anaesthetics and oxygen | Inhalational medicines |
| Isoflurane | GABA-A agonist, GluA1 inhibitor, GLYRA1 agonist | General anestesia | 1979 | Anaesthetics, preoperative medicines and medical gases | General anaesthetics and oxygen | Inhalational medicines |
| Ketamine | GluN antagonist | General and local anaesthesia | 1970 FDA | Anaesthetics, preoperative medicines and medical gases | General anaesthetics and oxygen | Injectable medicines |
| Lamotrigine | Nav inhibitor | Tonic-clonic seizures, epilepsy, Lennox-Gastaut syndrome | 1994 | Anticonvulsants/Antiepileptics | ||
| Lidocaine | Nav blocker | Local anaesthesia, neuralgia, itching, pediculosis, ventricular arrhythmia | 1948 | Anaesthetics, preoperative medicines and medical gases | Local anaesthetics | |
| Cardiovascular medicines | Antiarrhythmic medicines | |||||
| Lorazepam | GABAA activator | Anxiety, Myoclonic seizure, Atonic seizure, Status epilepticus | 1977 | Anticonvulsants/Antiepileptics | ||
| Midazolam | GABA-A activator | Anxiety, Anesthesia, Status epilepticus | 1985 | Anaesthetics, preoperative medicines and medical gases | Preoperative medication and sedation for short-term procedures | |
| Medicines for pain and paliative care | Medicines for other common symptoms in palliative care | |||||
| Anticonvulsants/Antiepileptics | ||||||
| Nicotine | Chrn agonist | Smoking cessation, nicotine dependence | Medicines for mental and behavioural disorders | Medicines for disorders due to psychoactive substance use | Nicotine replacement therapy | |
| Nifedipine | Cav1.x blocker | Hypertension, vasospastic angina, premature labor | 1981 | Medicines for reproductive health and perinatal care | Antioxytocics (tocolytics) | |
| Ondansetron | 5HT3A antagonist | Therapy-induced nausea and vomiting | 1991 FDA | Medicines for pain and paliative care | Medicines for other common symptoms in palliative care | |
| Gastrointestinal medicines | Antiemetic medicines | |||||
| Permethrin | Sodium channel (Sarcoptes scabiei) inhibitor | Infestation by Sarcoptes scabiei, Pediculosis | 1986 | Dermatological medicines (topical) | Scabicides and pediculicides | |
| Phenobarbital | GABA-A potentiator | Epilepsy, Lennox-Gastaut syndrome, migraine | 1912 | Anticonvulsants/Antiepileptics | ||
| Phenytoin | Nav inhibitor | Epilepsy | 1953 | Anticonvulsants/Antiepileptics | ||
| Propofol | GABA-A potentiator | General anaesthesia | 1989 FDA | Anaesthetics, preoperative medicines and medical gases | General anaesthetics and oxygen | Injectable medicines |
| Tetracaine | Nav inhibitor | Local anesthesia | 1941 | Ophtalmological preparations | Local anaesthetics | |
| Valproic acid | Nav inhibitor, GABAA modulator | Epilepsy, absence seizures, bipolar disorder, migraine | Anticonvulsants/Antiepileptics | |||
| Medicines for mental and behavioural disorders | Medicines used in bipolar disorders | |||||
| Verapamil | Cav1.x inhibitor | Hypertension, angina, supraventricular tachycardia, migraine, cluster headache | 1981 | Cardiovascular medicines | Antianginal medicines Antiarrhythmic medicines |