Ion channel drugs on the World Health Organization List of Essential Medicines 2019

WHO Essential Medicines are considered to be the most effective and safe medicines which satisfy the priority health care needs of the population. Here are Essential Ion Channel Medicines.

NameMechanism of actionIndicationYear of ApprovalType of medicineSubtype of medicineNote
AmilorideENaC inhibitorHypertensive disorder, edema, hypokalemia1981Diuretics
AmiodaroneKv11.1 blockerVentricular fibrillation, life-threatening ventricular tachycardia 1961Cardiovascular medicinesAntiarrhythmic medicinesComplementary List
AmlodipineCav1.x inhibitorHypertension, vasospastic angina, angina pectoris 1992Cardiovascular medicinesAntihypertensive medicines
AtracuriumChrn abd antagonistGeneral anaesthesia, muscle relaxation1983 FDAMucsle relaxants (peripherally acting) and cholinesterase inhibitors
BupivacaineNav inhibitorLocal anesthesia1972 FDAAnaesthetics, preoperative medicines and medical gasesLocal anaesthetics
CarbamazepineNav1.5 blockerEpilepsy, Lennox-Gastaut syndrome, bipolar disorder1968Anticonvulsants/Antiepileptics
Medicines for mental and behavioural disordersMedicines used in bipolar disorders
DiazepamGABA-A potentiatorAnxiety, alcohol withdrawal syndrome, spasticity, epilepsy1963 FDAMedicines for pain and paliative careMedicines for other common symptoms in palliative care
Anticonvulsants/Antiepileptics
Medicines for mental and behavioural disordersMedicines for anxiety disorders
DiazoxideKir6.2 activatorHypertensive emergencies, hyperinsulinism1973Medicines for endocrine disordersMedicines for hypoglycaemiaComplementary List
EthosuximideCav3.1 inhibitorAbsence seizures1960Anticonvulsants/AntiepilepticsComplementary List
GliclazideKir6.2 inhibitorDiabetes mellitus type 21972Medicines for endocrine disordersMedicines for diabetesOral hypoglycaemic agents
HalothaneGABA-A agonist, GluA1 inhibitor, GLYRA1 agonistGeneral anesthesia1958 FDAAnaesthetics, preoperative medicines and medical gasesGeneral anaesthetics and oxygenInhalational medicines
IsofluraneGABA-A agonist, GluA1 inhibitor, GLYRA1 agonistGeneral anestesia1979Anaesthetics, preoperative medicines and medical gasesGeneral anaesthetics and oxygenInhalational medicines
KetamineGluN antagonistGeneral and local anaesthesia1970 FDAAnaesthetics, preoperative medicines and medical gasesGeneral anaesthetics and oxygenInjectable medicines
LamotrigineNav inhibitorTonic-clonic seizures, epilepsy, Lennox-Gastaut syndrome 1994Anticonvulsants/Antiepileptics
LidocaineNav blockerLocal anaesthesia, neuralgia, itching, pediculosis, ventricular arrhythmia1948Anaesthetics, preoperative medicines and medical gasesLocal anaesthetics
Cardiovascular medicinesAntiarrhythmic medicines
LorazepamGABAA activatorAnxiety, Myoclonic seizure, Atonic seizure, Status epilepticus1977Anticonvulsants/Antiepileptics
MidazolamGABA-A activatorAnxiety, Anesthesia, Status epilepticus1985Anaesthetics, preoperative medicines and medical gasesPreoperative medication and sedation for short-term procedures
Medicines for pain and paliative careMedicines for other common symptoms in palliative care
Anticonvulsants/Antiepileptics
NicotineChrn agonistSmoking cessation, nicotine dependence Medicines for mental and behavioural disordersMedicines for disorders due to psychoactive substance useNicotine replacement therapy
NifedipineCav1.x blockerHypertension, vasospastic angina, premature labor1981Medicines for reproductive health and perinatal careAntioxytocics (tocolytics)
Ondansetron5HT3A antagonist Therapy-induced nausea and vomiting1991 FDAMedicines for pain and paliative careMedicines for other common symptoms in palliative care
Gastrointestinal medicinesAntiemetic medicines
PermethrinSodium channel (Sarcoptes scabiei) inhibitorInfestation by Sarcoptes scabiei, Pediculosis1986Dermatological medicines (topical)Scabicides and pediculicides
PhenobarbitalGABA-A potentiatorEpilepsy, Lennox-Gastaut syndrome, migraine1912Anticonvulsants/Antiepileptics
PhenytoinNav inhibitorEpilepsy1953Anticonvulsants/Antiepileptics
PropofolGABA-A potentiatorGeneral anaesthesia1989 FDAAnaesthetics, preoperative medicines and medical gasesGeneral anaesthetics and oxygenInjectable medicines
TetracaineNav inhibitorLocal anesthesia1941Ophtalmological preparationsLocal anaesthetics
Valproic acidNav inhibitor, GABAA modulator Epilepsy, absence seizures, bipolar disorder, migraine Anticonvulsants/Antiepileptics
Medicines for mental and behavioural disordersMedicines used in bipolar disorders
VerapamilCav1.x inhibitorHypertension, angina, supraventricular tachycardia, migraine, cluster headache1981Cardiovascular medicinesAntianginal medicines
Antiarrhythmic medicines