Ion channel drugs on the market

Here are the ion channel drugs which you can normally find on the market nowadays.
Updated August 2020

NameBrand namesMechanism of actionIndicationTypeYear of ApprovalCompany
AmlodipineNorvasc, AforbesCav1.x inhibitorHypertension, vasospastic angina, angina pectoris Small molecule1992Pfizer
AjmalineNav1.5 inhibitorArrhythmiaSmall Molecule
AlosetronLotronex5HT3A antagonistIrritable bowel syndrome with diarrheaSmall molecule2002 FDA
AlprazolamXanaxGABA-A positive modulatorAnxietySmall molecule1981 FDAUpjohn
AmantadineSymadine, OsmolexGluN inhibitorParkinson's diseaseSmall molecule
AmifampridineFirdapseKv blockerLambert-Eaton myasthenic syndromeSmall molecule2009BioMarin
AmilorideMidamorENaC inhibitorHypertensive disorder, edema, hypokalemiaSmall molecule1981
AmiodaroneCordaroneKv11.1 blockerVentricular fibrillation, life-threatening ventricular tachycardia Small molecule1961
AtracuriumChrn abd antagonistGeneral anaesthesia, muscle relaxationSmall Molecule1983 FDA
AzelnidipineCalBlock Cav1.x blockerHypertensionSmall MoleculeDaiichi-Sankyo
BenzocaineAnacaine, DermoplastNav blockerLocal anesthesia Small Molecule
Bioallethrin Sodium channel (Pediculus humanus) modulatorLice and scabies infestationSmall Molecule
BrexanoloneZulressoGABA-A positive modulatorPostpartum depressionSmall Molecule2019Sage Therapeutics
BupivacaineMarcaineNav inhibitorLocal anesthesiaSmall molecule1972 FDAHospira
ButalbitalSandoptal GABA-A potentiatorTension-type headacheSmall Molecule1976Actavis Labs
CapsaicinZostrix, QutenzaTRPV1 activatorNeuralgia, postherpetic neuralgia, backache, arthritic painSmall molecule2009 FDAAcorda Therapeutics
CarbamazepineActebral, TegretolNav1.5 blockerEpilepsy, Lennox-Gastaut syndrome, bipolar disorderSmall molecule1968Novartis
CarbutamideGlucidoralKir6.2 inhibitorDiabetes mellitus type 2Small molecule1956Servier
ChlordiazepoxideRisolidGABAA positive modulatorAnxiety, alcohol withdrawal syndromeSmall molecule1960 FDAValeant
ChloroprocaineNesacaineNav1.8 inhibitorLocal anesthesia Small Molecule
ChlorpropamideKir6.2 inhibitorDiabetes mellitus type 2Small molecule1958Pfizer
ChlorzoxazoneParafon, ParaflexKCa activatorSpasticity, muscle spasm with painSmall molecule1958Janssen
CilnidipineAtelec, CilogardCav1.x blocker, Cav2.2 blockerHypertensionSmall Molecule1995Fuji Viscera, Ajinomoto
CinchocaineDibucaine, NupercainalNav blockerLocal anesthesia Small Molecule
CinnarizineStugeron, CinazynCav inhibitorVertigo, motion sickness, nauseaSmall molecule1955Jansen Pharmaceutica
CisatracuriumNimbexChrn a1b1d inhibitorGeneral anaesthesia, muscle relaxationSmall molecule1995 FDA
ClevidipineCleviprexCav1.x blockerHypertensionSmall molecule2008The Medicines Company
ClobazamFrisium, Urbanol, Onfi, TapclobGABAA partial agonistEpilepsy, anxietySmall molecule2011Lundbeck
ClonazepamClonapam, RivotrilGABAA positive modulatorMyoclonic, atonic and absence seizures; Lennox-Gastaut syndromeSmall molecule1975Roche
ClorazepateTranxeneGABAA positive modulatorAnxiety, alcohol withdrawal syndrome, partial epilepsy Small molecule1972
ClotiazepamClozan GABA-A potentiatorAnxiety disordersSmall Molecule
CrofelemerMytesi, FulyzaqCFTR inhibitor, ANO1 inhibitorNon-infectious diarrheaSmall Molecule2012Salix Pharmaceuticals
CyclandelateCyclospasmol Cav alpha-2/delta-1 modulatorArteriosclerosis, Raynaud's diseaseSmall Molecule
DalfampridineAmpyra, FampyraKv blockerMultiple sclerosisSmall molecule2010Acorda Therapeutics
DantroleneDantriumRyR1 inhibitorSpasticity, malignant hyperthermia Small molecule1974Par Pharmaceutical
DesfluraneSupraneGABA-A agonist, GluA1 inhibitor, GLYRA1 agonistGeneral anestesiaSmall Molecule1992Baxter
DextromethorphanGluN3A antagonistCough, rhinitis, sneezingSmall Molecule1957ANI Pharmaceuticals
DiazepamValium, Diastat GABA-A potentiatorAnxiety, alcohol withdrawal syndrome, spasticity, epilepsySmall molecule1963 FDARoche
DiazoxideProglycemKir6.2 activatorHypertensive emergencies, hyperinsulinismSmall molecule1973
DiltiazemCardizem, TiazacCav1.x inhibitorHypertension, angina pectorisSmall molecule1982
DisopyramideNorpace, Ritmodan, DicorantilNav1.5 inhibitorVentricular arrhythmiaSmall molecule1977G.D. Searle LLC
DofetilideTikosynKir2.2, Kv10.1, Kv11.1 inhibitor Atrial fibrillation, atrial flutter Small molecule1999Pfizer
DronedaroneMultaqMultichannel blockerAtrial fibrillationSmall molecule2009 FDASanofi-Aventis
EfonidipineLandelCav1.x inhibitor, Cav3.x inhibitor HypertensionSmall molecule1995
EnfluraneEthrane, Alyrane GABA-A agonist, GluA1 inhibitor, GLYRA1 agonistGeneral anestesiaSmall Molecule1972Baxter
EslicarbazepineAptiom, Zebinix, ExaliefNav inhibitorPartial seizuresSmall molecule2009 EMA 2013 FDABial
EstazolamProsom, Eurodin, NuctalonGABAA potentiatorSevere InsomniaSmall molecule1990Abbott
EszopicloneLunestaGABA-A potentiatorInsomniaSmall molecule2004Sunovion
EthosuximideZarontinCav3.1 inhibitorAbsence seizuresSmall molecule1960Parke Davis
EtidocaineDuranestNav inhibitorLocal anesthesiaSmall molecule1976 FDA
FelbamateFelbatolGluN antagonistEpilepsy, Lennox-Gastaut syndromeSmall molecule1993 FDA
FelodipinePlendilCav1.x blocker, Cav3.x blockerHypertension, Angina pectoris prophylaxisSmall molecule1991AstraZeneca
FlecainideTambocorNav1.4 and Nav1.5 blockerAtrial fibrillation, atrial flutter, life-threatening ventricular tachycardiaSmall molecule1985
FlumazenilAnexate, RomaziconGABA-A antagonistBenzodiazepine induced sedation or toxicitySmall molecule1991 FDAHoffman La Roche
FlunarizineSibeliumCav3.x inhibitorMigraine, epilepsy, vertigoSmall molecule1968Jansen Pharmaceutica
FlunitrazepamHypnodorm GABA-A potentiatorSevere insomnia, anxietySmall Molecule1976
FlupirtineKatadolon Kv7.2-Kv7.5 activatorAcute and chronic painSmall molecule1984Asta-Medica
FlurazepamDalmadorm, DalmaneGABAA activatorInsomniaSmall molecule1970
FluspirileneRedeptin, ImapCav inhibitorSchizophreniaSmall molecule1963Jansen Pharmaceutica
FosphenytoinCerebyxNav1.5 blockerEpilepsySmall molecule1996Parke-Davis
FunapideTV-45070, XEN402Nav1.7 and Nav1.8 blockerChronic painSmall MoleculeXenon Pharmaceuticals
GabapentinNeurontinCav alpha-2/delta inhibitor, GluN inhibitorPostherpetic neuralgia, partial seizures Small molecule1993Pfizer
GlibenclamideDiabeta, GlyburideKir6.2 inhibitorDiabetes mellitus type 2Small molecule1984Sanofi Aventis
GlibornurideGlutrilKir6.2 inhibitorDiabetes mellitus type 2Small molecule1969/
GliclazideDiamicronKir6.2 inhibitorDiabetes mellitus type 2Small molecule1972
GlimepirideAmarylKir6.2 inhibitorDiabetes mellitus type 2Small molecule1995Sanofi Aventis
GlipizideGlucotrolKir6.2 inhibitorDiabetes mellitus type 2Small molecule1984Pfizer
GliquidoneGlurenormKir6.2 blockerDiabetes mellitus type 2Small Molecule
GlisoxepideKir6.x inhibitorDiabetes mellitus type 2Small molecule
GlyclopyramideDeamelinKir6.x inhibitorDiabetes mellitus type 2Small molecule1965
GlymidineGlycanol Kir inhibitorDiabetes mellitus type 2Small Molecule
GranisetronKytril5HT3A antagonist Therapy-induced nausea and vomitingSmall molecule1993 FDA
HalothaneGABA-A agonist, GluA1 inhibitor, GLYRA1 agonistGeneral anesthesiaSmall Molecule1958 FDA
HexylcaineCyclaineNav blockerLocal anesthesiaSmall MoleculeMerck
IbutilideCorvertKv11.1 blockerAtrial fibrillation, atrial flutterSmall Molecule1995
IsofluraneIsorane, AerraneGABA-A agonist, GluA1 inhibitor, GLYRA1 agonistGeneral anestesiaSmall Molecule1979Baxter
IsradipineDynaCirc, Prescal, Clivoten, Esradin, Lomir Cav1.x blockerHypertensionSmall molecule1989Sandoz (now division of Novartis)
IvabradineCorlanor, CorlentorHCN inhibitorChronic heart failure, angina pectorisSmall molecule2005 EMA 2015 FDAServier, Amgen
IvacaftorKalydecoCFTR potentiatorCystic fibrosisSmall molecule2012Vertex Pharmaceuticals
KetamineKetalarGluN antagonistGeneral and local anaesthesiaSmall molecule1970 FDA
KetazolamLoftran, Anseren GABA-A potentiatorAnxietySmall Molecule
LacidipineLacipil, MotensCav1.x blockerHypertensionSmall Molecule
LacosamideVimpatNav inhibitorPartial epilepsySmall molecule2008 FDA 2008 EMAUCB
LamotrigineLamictalNav inhibitorTonic-clonic seizures, epilepsy, Lennox-Gastaut syndrome Small molecule1994GSK
LeconotideCav2.2 blockerPainPeptide
LercanidipineZanidipCav1.x inhibitorHypertensionSmall molecule1997
LevamlodipineAsomex, Espin Cav1.x blockerHypertension, anginaSmall Molecule
LevobupivacaineChirocaineNav inhibitorLocal anesthesiaSmall molecule1999 FDAPurdue pharma
Levomenthol MentholTRPM8 agonistMinor irritation, pain, sore mouth, sore throat, itching, local anesthesiaSmall Molecule
LidocaineXylocaineNav blockerLocal anaesthesia, neuralgia, itching, pediculosis, ventricular arrhythmiaSmall molecule1948Fresenius Kabi
LorazepamAtivanGABAA activatorAnxiety, Myoclonic seizure, Atonic seizure, Status epilepticusSmall molecule1977 FDAWyeth Pharmaceuticals
LormetazepamGABA-A potentiatorShort-term insomniaSmall Molecule
LubiprostoneAmitizaCLC-2 activatorChronic idiopathic constipationSmall Molecule2006Sucampo Pharmaceuticals
LumacaftorOrkambi (a combination of ivacaftor and lumacaftor)CFTR modulatorCystic fibrosisSmall molecule2015Vertex Pharmaceuticals
ManidipineCalslot, ManyperCav1.x and Cav3.x blockerHypertensionSmall Molecule
MavatrepTRPV1 antagonistPainSmall MoleculeJanssen
MemantineAxura, NamendaGluN antagonistModerate to severe Alzheimer's type dementiaSmall molecule2003Forest labs
MepivacaineCarbocaineNav inhibitorLocal anesthesiaSmall molecule1960 FDAHospira, Inc., Pfizer
MethoxyfluranePenthroxGABA-A activator, GluA1 inhibitor, GLYRA1 agonistGeneral anestesiaSmall MoleculeAbbott
MethsuximidePetinutinCav3.x blockerAbsence seizures, epilepsy Small Molecule1957Parke Davis
MexiletineMexitilNav inhibitorVentricular arrhythmiaSmall molecule1985
MidazolamBuccolam, VersedGABA-A activatorAnxiety, Anesthesia, Status epilepticusSmall molecule1985
MinoxidilLonitenKir6.2 activatorHypertension, alopecia Small molecule1979 FDA
MirogabalinTarligeCav ?2? modulatorPeripheral neuropathic painDaiichi Sankyo
NateglinideStarlixKir6.2 blockerDiabetes mellitus type 2Small molecule2000 FDANovartis
NicardipineCardeneCav1.x inhibitorHypertension, angina pectorisSmall molecule1988
NicorandilIkorel, DancorKir6.2 activatorAngina pectorisSmall molecule1984
NicotineNicorette, NicotrolChrn agonistSmoking cessation, nicotine dependence Small molecule
NifedipineAdalat, Procardia, Afeditab, Nifediac Cav1.x blockerHypertension, vasospastic angina, premature laborSmall molecule1981Pfizer
NilvadipineEscor, Escor forte, Naftdil, Nilvadipine, Nivadil, Towajilcalcium channel blockerhypertension, vasospastic angina, chronic stable anginaSmall MoleculeAstellas Pharma, Archer Pharmaceuticals
NimodipineNimotop, NymalizeCav1.x blockerSubarachnoid hemorrhage, hypertensionSmall molecule1988
NisoldipineSularCav1.x blockerHypertensionSmall Molecule1995Shionogi
NitrazepamMogadon, Alodorm, NitrazadonGABA-A potentiatorInsomniaSmall molecule1965
NitrendipineBaypress, Nidrel Cav1.x blockerHypertensionSmall Molecule1985
OndansetronZophren5HT3A antagonist Therapy-induced nausea and vomitingSmall molecule1991 FDAGSK
OxazepamNovoxapam, Alepam GABA-A potentiatorAnxiety, alcohol withdrawal deliriumSmall molecule1965
OxcarbazepineTrileptalNav1.5 blockerEpilepsySmall molecule1990
OxybuprocaineNovesine, NovesinNav inhibitorLocal anesthesia Small Molecule
PalonosetronAloxi5HT3A antagonistChemotherapy-induced nausea and vomitingSmall molecule2003 FDA 2009 EMAHelsinn Healthcare
PentoliniumNACHR antagonistHypertensionSmall MoleculeWyeth Pharmaceuticals
PerampanelFycompaGluA1-4 antagonistPartial seizuresSmall molecule2012 FDAEisai
PermethrinElimiteSodium channel (Sarcoptes scabiei) inhibitorInfestation by Sarcoptes scabiei, PediculosisSmall Molecule1986
PhenobarbitalLuminalGABA-A potentiatorEpilepsy, Lennox-Gastaut syndrome, migraineSmall molecule1912
PhensuximideMilontinCav inhibitor Nav inhibitorEpilepsy, absence seizuresSmall moleculeFDAParke Davis
PhenytoinDilantinNav inhibitorEpilepsySmall molecule1953Parke Davis
PinacidilPindac Kir6.2 activatorHypertensionSmall molecule1989 FDALeo Pharma
PinaveriumDicetelCav1.x antagonistIrritable bowel syndrome Small molecule1975 Solvay Pharmaceuticals
PregabalinLyricaCav alpha-2/delta modulatorDiabetic peripheral neuropathy, postherpetic neuralgiaSmall molecule2004
PrilocaineCitanest, Xylonest Nav inhibitorLocal anaesthesia, premature ejaculationSmall molecule1965
PrimidoneMysolineGABA-A positive modulatorEpilepsy, Lennox-Gastaut syndromeSmall molecule1954 FDAValeant
ProcainamidePronestyl, Procan-SR, ProcanbidNav inhibitor, Kv11.1 inhibitorLife-threatening ventricular tachycardiaSmall molecule1950Bristol-Meyers Squibb
ProcaineNovocaineNav1.8 blockerLocal anesthesia Small Molecule1954
PropafenoneRythmolNav1.5 blockerAtrial fibrillation, atrial flutter, life-threatening ventricular tachycardiaSmall molecule1989GSK
ProparacaineAlcaine, OphtheticNav blockerLocal anesthesiaSmall Molecule1953
PropofolDiprivanGABA-A potentiatorGeneral anaesthesiaSmall molecule1989 FDAFresenius Kabi
QuazepamDoral, DormalinGABA-A potentiatorInsomniaSmall molecule1985Sciencure Pharma
QuinidineCardioquin, QuinidexNav inhibitorAtrial fibrillation, malaria, life-threatening ventricular tachycardiaSmall Molecule1950Lilly
RanolazineRanexaNav inhibitorAngina pectorisSmall molecule2006Gilead
RepaglinideGluconorm, Prandin, Novonorm Kir6.2 blockerDiabetes mellitus type 2Small molecule1997Novo Nordisk
RiluzoleRilutekKCa2.3 activator, Nav1.5 inhibitor Amyotrophic lateral sclerosisSmall molecule1995 FDA
RocuroniumZemuron, EsmeronChrn a1b1d/g antagonistGeneral anaesthesia, muscle relaxationSmall molecule1994 FDA
RopivacaineNaropinNav blockerLocal anaesthesiaSmall molecule1996Fresenius Kabi
RufinamideBanzelNav modulatorLennox-Gastaut syndromeSmall Molecule2007 EMA 2008 FDANovartis
SafinamideXadagoNav and Cav inhibitorParkinson’s diseaseSmall Molecule2015 EMA 2017 FDANewron Pharmaceuticals
SevofluraneUltane, SojournGABA-A activator, GLYRA1 agonistGeneral anestesiaSmall Molecule1995Abbvie
SotalolBiosotal, SotalexKv11.1 blockerAtrial fibrillation, life-threatening ventricular tachycardia Small molecule1974
StiripentolDiacomitGABA-A positive modulatorMyoclonic seizuresSmall Molecule2007 EMA 2018 FDABiocodex
SuccinylcholineAnectineChrn a1b1deg agonistGeneral anaesthesia, muscle relaxationSmall molecule1952 FDASandoz
TemazepamRestorilGABA-A potentiatorInsomniaSmall molecule1981Mallinckrodt Pharmaceuticals
TetracainePontocaineNav inhibitorLocal anesthesiaSmall molecule1941
TezacaftorCFTR activatorCystic fibrosisSmall Molecule2018Vertex Pharmaceuticals
TocainideTonocard Nav blockerVentricular arrhythmiaSmall Molecule1984
TolazamideTolinase, Norglycin Kir6.2 inhibitorDiabetes mellitus type 2Small molecule1966
TolbutamideKir6.2 inhibitorDiabetes mellitus type 2Small molecule1961 FDA
TopiramateTopamaxGABA-A positive modulator, Nav blocker, GluA antagonistEpilepsy, migraine, Lennox-Gastaut syndrome Small Molecule
TriamtereneDyreniumENaC inhibitorHypertensive disorder, edemaSmall molecule1964Smith Kline & French
TriazolamHalcionGABA-A positive modulator InsomniaSmall molecule 1982 (withdrawn in the UK)Pharmacia and Upjohn
TrimebutineTrimebutineCav1.x inhibitor, KCa inhibitorIrritable bowel syndrome, postoperative paralytic ileusSmall Molecule
TrimethadioneTridioneCav3.1 inhibitorAbsence seizures, epilepsy Small Molecule1946Abbvie
UnoprostoneResculaBK and CLC-2 activatorOcular hypertension, open-angle glaucomaSmall Molecule2000 FDA (discontinued in the US)Sucampo Pharmaceuticals
Valproic acidConvulex, Depakene, ValcoteNav inhibitor, GABAA modulator Epilepsy, absence seizures, bipolar disorder, migraine Small molecule
VareniclineChantix, ChampixChrn a4b2 agonistSmoking cessationSmall molecule2006 FDAPfizer
VerapamilCalan, VerelanCav1.x inhibitorHypertension, angina, supraventricular tachycardia, migraine, cluster headacheSmall molecule1981
VernakalantBrinavessNav1.5, Kv1.5, Kv4.3 blockerAtrial fibrillationSmall Molecule2010, EMACardiome Pharma
XEP-018NaV1.4 blockerSkin wrinklesSynthetic peptideActiven
ZaleplonSonataGABA-A agonistInsomniaSmall Molecule1999Meda Ab, Pfizer
ZiconotidePrialtCav2.2 blockerSevere and chronic painSynthetic peptide2004Elan Pharmaceuticals
ZolpidemAmbienGABA-A agonistInsomniaSmall molecule1992Sanofi Aventis
ZonisamideZonegranNav blocker, Cav3.x blockerPartial epilepsySmall Molecule2000Eisai
ZopicloneImovane, ZimovaneGABA-A potentiatorInsomniaSmall molecule1986Rhône-Poulenc
ZucapsaicinZuactaTRPV1 agonistSevere pain associated with osteoarthritis of the knee, neuropathic painSmall MoleculeSanofi Aventis