Past Events
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Inward cardiac sodium current in health and disease – Prof. Silvia Priori, University of Pavia
Silvia Priori's lab studies mechanisms of genetic arrhythmias.
Blog
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Ephaptic coupling and the magical channels
Ion channels perform real magic by enabling cells to control other cells from a distance, much like magicians who move objects on the stage without physical contact.
Past Events
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7th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets
This symposium, the 7th in an ongoing series, will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.
Industry
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Axalbion to Present Promising Phase 2 Clinical Data in Chronic Cough with AX-8, a Novel TRPM8 Agonist
Source: Axalbion
Events
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Cambridge Ion Channel Forum
Metrion Biosciences and AstraZeneca are delighted to be co-hosting the 2023 Cambridge Ion Channel Forum at the Babraham Research Campus Conference Centre on the afternoon of Wednesday 10th May 2023. You will have the opportunity to enjoy a series of presentations from esteemed ion channel scientists, promote your research during the dedicated poster session and network with other ion channel enthusiasts.
Events
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Cardiac Safety Symposium 2023
At the Cardiac Safety Symposium you can learn about newest insights on current challenges in safety pharmacology, cardiac physiology, electrophysiology and contractility assessments of stem cell-derived and native cardiomyocytes.
Industry
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NRx Pharmaceuticals Announces Close of $2.9 Million Registered Direct Offering
NRx Pharmaceuticals
Industry
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QurAlis Closes $88 Million Series B Financing to Advance Precision Medicines for Neurodegenerative Diseases
Source: QurAlis
Industry
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Praxis Announces Topline Results from the Essential1 Study of Ulixacaltamide for the Treatment of Essential Tremor
Source: Praxis Precision Medicines
Blog
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Ion channels and rare diseases
How many rare diseases are related to ion channels? I used data from OrphaData.com to figure it out.
Past Events
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Novel Patch Clamp to Advance Pain Research
In this webinar, attendees will gain insight into the realm of automated patch clamp assays, exploring the mechanisms of pain.
Past Events
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Cardiac ephaptic coupling and interactions between sodium channels: myths or realities? – Prof. Jan Kucera, University of Bern
Ephaptic interactions mediated by extracellular potentials might contribute to cardiac conduction when gap junctional coupling is reduced, but this mechanism is still controversial.
Past Events
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Biophysical Society Annual Meeting
The Biophysical Society annual meetings are the largest annual gathering of biophysicists around the world.
Industry
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Maxion Therapeutics raises $16 million to develop novel biologics targeting ion channels and GPCRs
Source: Maxion Therapeutics
Past Events
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Acid-activated Cl-Channel ASOR/TMEM206: A Previously Enigmatic Channel with Roles in Endosomes – Dr. Thomas Jentsch, Max Delbrück Center for Molecular Medicine, Berlin
The acid-sensitive chloride ion channel ASOR is found in almost all our cells. ASOR plays a role in acid-induced cell death, but a role in intracellular processes, for example in the transport of vesicles, is now coming to the fore.
Blog
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Exciting channel Nav1.6
Today is SCN8A Awareness Day, so let's take a deeper look at SCN8A channel (Nav1.6) and find out what makes it so special.
Blog
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Funny channels
February 8 is Laugh And Get Rich Day. So, I looked through Pubmed to find out how ion channels are related to laughter.
Blog
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The Scent of Roses and the mighty Nav1.7
Read how one tiny but mighty ion channel can keep us from enjoying the scent of roses.
Industry
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FDA Accepts Filing of New Drug Application and Grants Priority Review of Zuranolone
Source: Sage Therapeutics
Blog
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Why does wasabi burn the nose?
When we eat it, wasabi primarily burns the nose and upper throat, while chili pepper mostly burns the tongue and mouth. Do you know why?
Blog
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Sweet TRPM5
Do you know why hot chocolate tastes sweeter than cold chocolate? Because of ... obviously, ion channels.
Blog
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Feed the birds with chili peppers
One interesting fact about birds is that they are insensitive to “hot” chili peppers.
Industry
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Karuna Therapeutics to obtain global development, manufacturing, and commercialization rights to Goldfinch Bio’s investigational TRPC4/5 channel candidates.
Source: Karuna Therapeutics
Research
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Mechanical forces caused by foetal movements drive skeletal development
Source: University College Dublin
New study identifies the TRPV4 channel as playing a key role in translating mechanical signals from a baby's movement in the womb to healthy development of the skeleton.
Past Events
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Dravet syndrome mouse models for novel gene therapy development – Dr Moran Rubinstein, Tel Aviv University
Dravet syndrome is severe childhood-onset epilepsy, caused by loss of function mutations in the SCN1A gene. Novel therapies aim to restore SCN1A expression in order to address all disease manifestations.
Industry
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Sygnature Discovery completes acquisition of SB Drug Discovery to further strengthen its market-leading capabilities
Source: SB Drug Discovery
Research
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Treating gut pain via a Nobel prize-winning receptor
Source: Flinders University
Targeting Piezo2 could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome.
Industry
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Catalyst Pharmaceuticals to Acquire U.S. Commercial Rights to FYCOMPA® (Perampanel) CIII From Eisai Co., Ltd
Source: Catalyst Pharmaceuticals
Industry
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Gilgamesh Pharmaceuticals Raises $39 Million Series B to Advance Mental Health Treatments
Source: PRNewswire
Careers
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Post-doctoral position in the Paoletti lab to study unconventional iGluRs
Source: Paoletti Lab
Industry
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Sionna Therapeutics Announces IND Clearance and Phase 1 Initiation for SION-638 in Cystic Fibrosis
Source: Sionna Therapeutics
Industry
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Bionomics’ Social Anxiety Disorder Lead Candidate Failed to Hit the Primary Endpoint in Phase 2 Study
Source: Bionomics
Industry
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Praxis Precision Medicines partners with UCB to discover potential treatments for KCNT1-related epilepsies
Source: Praxis Precision Medicines
Industry
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Relmada’s lead candidate REL-1017 (NMDAR blocker) did not achieve its primary endpoint in a Phase III study, evaluating it as an adjunctive treatment for MDD
Source: Relmada Therapeutics
Industry
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Algernon Pharmaceuticals Receives U.S. FDA Orphan Drug Designation for Ifenprodil for the Treatment of Idiopathic Pulmonary Fibrosis
Source: Algernon Pharmaceuticals
Research
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Researchers developed a method to target specific neurons and change their excitability with light for long periods of time
Source: Harvard John A. Paulson School of Engineering and Applied Sciences
A new method for modulating neural activity using optogenetic polymerization and assembly of electroactive polymers on specified cellular membranes.
Industry
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Metrion Biosciences and The KCNC1 Foundation collaborate on development of new ion channel modulators for ultra-rare genetic disorder
Source: Metrion Biosciences
Careers
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Post-Doctoral Research Fellow in Cell Biology – BK channels
Source: Dundalk Institute of Technology
Research
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Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy
Source: Children's Hospital of Philadelphia
The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disorder.
Industry
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Metrion Biosciences invests in new High Throughput Screening capability and expanded facilities
Source: Metrion Biosciences
Past Events
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Ion channels and cancer meeting 2022
This meeting will be dedicated to exploring ion channel regulation from molecular biophysics to physiology and clinical applications in cancer biology. Meeting will also include one ECS session: "Calcium signaling in cancer".
Past Events
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Voltage-gated sodium channels and cancer – Dr William Brackenbury, University of York
Repurposing VGSC-inhibiting medications to cancer may hold promise for reducing metastasis.
Industry
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Gate Neurosciences Doses First Subject in a Translational EEG Biomarker Study of Apimostinel, a Rapid-Acting Treatment for Acute Depressive Disorders
Source: Gate Neurosciences
Industry
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Axsome Therapeutics Announces AXS-05 Achieves Primary Endpoint in the ACCORD Phase 3 Trial in Alzheimer’s Disease Agitation
Source: Axsome Therapeutics
Past Events
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Membrane proteins and mechanisms of disrupted cellular homeostasis – Anna Greka, Harvard Medical School, USA
Anna Greka leads a program focused on dissecting fundamental mechanisms of disrupted cellular homeostasis in genetically-defined kidney, metabolic and degenerative diseases...
Past Events
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Understanding the function of sodium channel accessory proteins using pain-causing toxins – Prof Irina Vetter, University of Queensland
The pharmacological activity of pain-causing toxins can provide critical insights into the molecular mechanisms underpinning sensory neuron function and pain...
Industry
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Kriya acquires Redpin Therapeutics, adding its ion channel-based chemogenetics platform and pipeline to gene therapy engine
Source: Kriya Therapeutics
Research
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New test can help patients with cystic fibrosis
Source: Aarhus University
Challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.
Past Events
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Gain-of-function mutations in Nav1.6 and epileptic seizures – Dr Manoj Patel, University of Virginia.
Many de novo missense mutations of SCN8A, the gene that encodes for Nav1.6, have been identified and patients have seizure onset between birth and 12 months of age...
Events
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Ion Channels in Synaptic and Neural Circuit Physiology
The primary goal of this course is to demonstrate, through lectures and laboratory work, the different biophysical properties of ion channels that enable neurons to perform unique physiological functions in various neural systems.
Events
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The Calcium and Cell Function Conference
The program will address the rapidly moving research on receptor-regulated calcium signaling and the critical questions that are key to establishing future therapies for cardiovascular, airway, gut, liver, immunoinflammatory, metabolic and neurological disorders.
Events
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38th Microelectrode Techniques for Cell Physiology Workshop
The Microelectrode Techniques for Cell Physiology Workshop provides postgraduate and postdoctoral researchers with both hands-on and theoretical training in electrophysiological and associated techniques.
Events
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1st NALCN workshop: The Sodium Leak Channel in health and disease
This workshop aims to cover all aspects of NALCN research, including involvement of patient families & physicians, and research highlighting in vivo studies, along with NALCN molecular structure and function.
Events
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2nd International Kv7 Channels Symposium 2023
This symposium will showcase the myriad aspects of Kv7 research, with emphasis on emerging research areas.
Events
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Mapping the Pain Landscape: From Molecules to Medicine
This 2023 SGP Meeting will be focused on the topic of pain and will offer an excellent opportunity for participants to interact with leading scientists tackling impactful questions in the pain field, from the biophysical to behavioral level.
Research
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Scientists uncover potential “electrical language” of breast cancer cells
Source: Imperial College London
The high-throughout, cellular-resolution imaging data indicate that Vm fluctuates dynamically in subpopulations of highly aggressive breast cancer cell lines.
Research
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Pacemaker Channel Discovery Could Lead to Better Heart Drugs
Source: Weill Cornell Medicine
Anionic lipids unlock the gates of select ion channels in the pacemaker family
Research
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Gene therapy targeting overactive brain cells could treat neurological disorders
Source: University College London
UCL researchers developed a gene therapy strategy that self-selects pathologically overactive neurons and down-regulates their excitability via controlled expression of Kv1.1.
Research
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Extracellular fluid viscosity enhances cell migration and cancer dissemination
Source: Johns Hopkins Medicine
Elevated viscosity counterintuitively increases the motility of various cell types in a TRPV4-dependent manner.
Research
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Study Identifies Potential New Treatment Target for Sleep Apnea
Source: Johns Hopkins Medicine
TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
Events
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The Channelopathy Conference 2024
World-renowned speakers, pioneers in the field of channelopathies, will present their latest discoveries.
Industry
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Sophion Bioscience and Sussex Drug Discovery Centre strengthen collaboration
Source: Sophion Bioscience
Industry
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Relmada Therapeutics reported a Phase III fail for its lead NMDAR blocker, REL-1017, in major depressive disorder
Source: Relmada Therapeutics
Industry
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Adult mammalian cardiomyocytes successfully recorded for the first time on a high throughput automated patch clamp system
Source: Nanion Technologies
Industry
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Biohaven Sets New Course with $258 Million in Cash and Deep Pipeline to Advance Science for Patients
Source: Biohaven
Industry
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Jaguar Health Subsidiary Napo Pharmaceuticals Announces Activation by FDA of IND Application for NP-300 (Lechlemer)
Source: Jaguar Health
Industry
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FDA grants Orphan Drug Designation for NMD670 for the Treatment of Myasthenia Gravis
Source: NMD Pharma
Research
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TRPC6 Blocking Improves Muscle Function and Survival in Mice with Severe Duchenne Muscular Dystrophy
Source: Johns Hopkins Medicine
Researchers discovered that blocking the TRPC6 channel in genetically modified mice with severe or moderate Duchenne muscular dystrophy substantially improves their skeletal and cardiac muscle function, bone deformities and survival.
Industry
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Gate Neurosciences Emerges from Stealth with a Portfolio of Next-Generation Therapies for CNS Diseases
Source: Gate Neurosciences
Industry
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Alcon to Acquire Aerie Pharmaceuticals, Inc., Enhancing its Ophthalmic Pharmaceutical Portfolio
Source: Aerie Pharmaceuticals
Industry
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Aerie Pharmaceuticals Announces First Participant Dosed in the COMET-3 Study of its TRPM8 agonist AR-15512 for the Treatment of Dry Eye Disease
Source: Aerie Pharmaceuticals
Industry
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The SyncroPatch 384 from Nanion has been installed at the MBExC Cluster of Excellence at the University Medical Centre Göttingen
Source: Nanion Technologies
Research
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A New Mechanism Responsible for Controlling Auditory Sensitivity
Source: University of Colorado
cAMP and voltage modulate rat auditory mechanotransduction by decreasing the stiffness of gating springs.
Research
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New findings reveal how neurons build and maintain their capacity to communicate
Source: MIT
While the biosynthesis of the voltage-gated Ca2+ channels does not play a major role in regulating their abundance at presynaptic active zones, both trafficking and recycling at active zones are important regulatory steps.
Research
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Opening New Doors: First Synthetic Mechanosensitive Potassium Channel
Source: Tokyo Institute of Technology
Inspired by mechanosensitive potassium channels found in nature, researchers have developed the first synthetic mechanosensitive potassium channel.
Research
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Breaking the vicious itch-scratch cycle by targeting ‘miswired’ neurons
Source: Fierce Biotech
Researchers showed that the Piezo2 channels in Merkel cells are responsible for the itch triggered by mechanical stimulation in dry skin.
Research
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Researchers discovered novel light-gated potassium channel
Source: The University of Texas Health Science Center at Houston
Researcher have discovered two naturally occurring channelrhodopsins enabling optogenetic control of K+ gradients, which is promising for the study and potential treatment of potassium channelopathies such as epilepsy, Parkinson’s disease and long-QT syndrome and other cardiac arrhythmias.
Industry
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Metrion Biosciences appoints Dr Benedetta Montagnini as Head of European Business Development
Source: Metrion Biosciences
Industry
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Newron shows encouraging results for evenamide (Nav channel inhibitor) in patients with treatment-resistant schizophrenia
Source: Newron Pharmaceuticals
Industry
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Aerie Pharmaceuticals Announces First Participant Dosed in the Phase 3 Registrational COMET-2 Study of AR-15512 for the Treatment of Dry Eye Disease
Source: Aerie Pharmaceuticals
Research
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Research reveals surprising inactivation mechanism for a voltage-gated ion channel
Source: St. Jude Children’s Research Hospital
New findings elucidate mechanisms of closed-state inactivation and voltage-dependent activation of the KV4 channel.
Industry
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NMD Pharma expands its US presence with the creation of NMD Pharma US, Inc.
Source: NMD Pharma
Industry
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The SyncroPatch 384 from Nanion is installed at the FDA for cardiac safety pharmacology studies
Source: Nanion Technologies
Industry
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Bridge Biotherapeutics Enters into an Option-to-License Agreement with CellionBioMed to Develop BBT-301 for the Treatment of Multiple Fibrotic Diseases
Source: Bridge Biotherapeutics
Industry
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David Clapham joins Caraway Therapeutics as a scientific advisor
Source: Caraway Therapeutics
Research
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Gene therapy inspired by bacteria shows promise for cardiac conduction disorders
Source: Fierce Biotech
Scientists demonstrated that prokaryotic sodium channels can be directly, specifically, and stably expressed in cardiomyocytes through viral gene delivery to augment tissue excitability and conduction.
Industry
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Morphoceuticals Inc. Hails Successful Limb Regeneration in Adult Frogs
Source: Business Wire
Industry
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CalciMedica Initiates CARDEA-Plus: A Clinical Trial of Auxora™ in Patients with Critical COVID-19 Pneumonia
Source: CalciMedica
Industry
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Sophion introduced QPatch Compact – a new bench-top semi-automated patch clamp system
Source: Sophion Bioscience
Industry
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Metrion Biosciences and Bioqube Ventures collaborate to identify Kv1.3 inhibitors for autoimmune disorders
Source: Metrion Biosciences
Industry
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Metrion Biosciences expands ion channel drug discovery service capabilities and in-house expertise
Source: Metrion Biosciences
Industry
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Metrion Biosciences appoints Rory Curtis as Vice President US Commercial Operations
Source: Metrion Biosciences
Research
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A striking difference between neurons of humans and other mammals
Source: MIT
Human neurons have fewer ion channels compared to the neurons of other mammals.
Industry
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Metrion Biosciences expands into new headquarters to support continued growth
Source: Metrion Biosciences
Industry
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Metrion Biosciences appoints Nick Foster as Chief Commercial Officer and Head of Global Business Development
Source: Metrion Biosciences
Industry
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Saniona initiates Phase 1 clinical trial of SAN711 for the treatment of rare neuropathic disorders
Source: Saniona
Industry
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Sophion Bioscience and Genedata Announce New Genedata Ready-to-Run Partnership
Source: Sophion Bioscience
Industry
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Caraway Therapeutics and AbbVie join forces to develop novel TMEM175 modulators for Parkinson’s disease and other neurodegenerative disorders
Source: Caraway Therapeutics
Industry
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Metrion Biosciences appoints Mark Keogh as Non-Executive Director
Source: Metrion Biosciences
Industry
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Metrion Biosciences raises £2.7m and adds GLP cardiac safety services to the suite of ion channel drug discovery services
Source: Metrion Biosciences
Industry
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CalciMedica Raises $21 Million in Series D Financing to support the clinical development of CRAC channel inhibitors
Source: CalciMedica
Industry
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Soleno Therapeutics collaborates with Vanderbilt University to discover and develop novel KATP channel activators for the treatment of rare diseases
Source: Soleno Therapeutics
Industry
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Metrion Biosciences appoints John Montana as Non-Executive Director
Source: Metrion Biosciences
Industry
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Metrion Biosciences collaborates with Sosei Heptares to Explore Structure-based Drug Discovery Approaches to Ion Channels
Source: Metrion Biosciences
Research
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Chemists discover the structure of a key coronavirus protein
Source: MIT
An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity.
Research
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Outstanding ion channel scientists receive honorary awards
October 2020 has really become a month of awards for ion channel researchers.
Blog
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Is crowdfunding an option to finance your research?
Discover the platforms for crowdfunding scientific research in this article.
Blog
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What is an ion?
Outside of science, many people have a completely different idea of what an "ion" actually means.
Research
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Ardem Patapoutian and David Julius have won the 2020 Kavli Prize in Neuroscience
Source: The Kavli Prize
The Norwegian Academy of Science and Letters has decided to award the 2020 Kavli Prize in Neuroscience to David Julius and Ardem Patapoutian “for their transformative discovery of receptors for temperature and pressure.”
Industry
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Nanion Technologies and NEXEL partner to open a new reference demonstration laboratory in South Korea
Source: Nanion Technologies
Analytics
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Trends in ion channel paper authorship
This article shows how authors are distributed over ion channel papers (the number of authors per paper).
Analytics
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How many ion channel scientists are there?
How many ion channel scientists, labs, companies are there in the world? See the estimate in this article.
Analytics
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TOP ion channel-friendly journals
The choice of the journal for publishing your research is a strategic decision. This article will help you to chose the ion channel-friendly journal to publish your research in.
Analytics
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Ion channel journal trends
How many journals publish ion channel-related research? Do we need a lot of journals?
Blog
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Extraordinary ordinary patch-clamp
The paper on patch-clamping by Erwin Neher and Bert Sakmann (1976) has been selected as 1 out of 10 extraordinary Nature papers.
Fundamentals
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Membrane transport
Every cell possesses a variety of sophisticated membrane transport systems allowing for control of the intracellular environment.
Blog
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The classic paper by Neher and Sakmann is 1 out of 10 key Nature papers
The patch-clamp technique has been described by Nature journal as “a breakthrough method that became vital to neuroscience”.
Fundamentals
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History of ion channels
Before the 1660s the Theory of Animal Spirits dominated thinking regarding the function of the nervous system. “Animal spirits” (originating in the brain) were believed to control movements of the body by flowing through the nerves into the muscles.
Analytics
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Ion channel publication trends
Here is the outlook of an ion channel research productivity expressed in the number of ion channel-related papers per year.
Fundamentals
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Nobel Prizes
The scientific community has recognized the crucial importance of ion channel research by four Nobel Prizes for the discoveries concerning the structure and function of ion channels.
Fundamentals
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Why we should care about ion channels
“… ion channels are the most important single class of proteins that exist in the human body or any body…” - Clay Armstrong
Research
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