Research
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Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy
Source: Children's Hospital of Philadelphia
The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disorder.
Industry
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Metrion Biosciences invests in new High Throughput Screening capability and expanded facilities
Source: Metrion Biosciences
Events
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Ion channels and cancer meeting 2022
This meeting will be dedicated to exploring ion channel regulation from molecular biophysics to physiology and clinical applications in cancer biology. Meeting will also include one ECS session: "Calcium signaling in cancer".
Industry
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Gate Neurosciences Doses First Subject in a Translational EEG Biomarker Study of Apimostinel, a Rapid-Acting Treatment for Acute Depressive Disorders
Source: Gate Neurosciences
Past Events
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Membrane proteins and mechanisms of disrupted cellular homeostasis – Anna Greka, Harvard Medical School, USA
Anna Greka leads a program focused on dissecting fundamental mechanisms of disrupted cellular homeostasis in genetically-defined kidney, metabolic and degenerative diseases...
Past Events
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Understanding the function of sodium channel accessory proteins using pain-causing toxins – Prof Irina Vetter, University of Queensland
The pharmacological activity of pain-causing toxins can provide critical insights into the molecular mechanisms underpinning sensory neuron function and pain...
Industry
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Kriya acquires Redpin Therapeutics, adding its ion channel-based chemogenetics platform and pipeline to gene therapy engine
Source: Kriya Therapeutics
Research
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New test can help patients with cystic fibrosis
Source: Aarhus University
Challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.
Past Events
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Gain-of-function mutations in Nav1.6 and epileptic seizures – Dr Manoj Patel, University of Virginia.
Many de novo missense mutations of SCN8A, the gene that encodes for Nav1.6, have been identified and patients have seizure onset between birth and 12 months of age...
Events
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7th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets
This symposium, the 7th in an ongoing series, will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.
Events
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Mapping the Pain Landscape: From Molecules to Medicine
This 2023 SGP Meeting will be focused on the topic of pain and will offer an excellent opportunity for participants to interact with leading scientists tackling impactful questions in the pain field, from the biophysical to behavioral level.
Research
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Scientists uncover potential “electrical language” of breast cancer cells
Source: Imperial College London
The high-throughout, cellular-resolution imaging data indicate that Vm fluctuates dynamically in subpopulations of highly aggressive breast cancer cell lines.
Research
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Pacemaker Channel Discovery Could Lead to Better Heart Drugs
Source: Weill Cornell Medicine
Anionic lipids unlock the gates of select ion channels in the pacemaker family
Research
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Gene therapy targeting overactive brain cells could treat neurological disorders
Source: University College London
UCL researchers developed a gene therapy strategy that self-selects pathologically overactive neurons and down-regulates their excitability via controlled expression of Kv1.1.
Research
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Extracellular fluid viscosity enhances cell migration and cancer dissemination
Source: Johns Hopkins Medicine
Elevated viscosity counterintuitively increases the motility of various cell types in a TRPV4-dependent manner.
Research
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Study Identifies Potential New Treatment Target for Sleep Apnea
Source: Johns Hopkins Medicine
TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
Industry
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Sophion Bioscience and Sussex Drug Discovery Centre strengthen collaboration
Source: Sophion Bioscience
Industry
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Relmada Therapeutics reported a Phase III fail for its lead NMDAR blocker, REL-1017, in major depressive disorder
Source: Relmada Therapeutics
Industry
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Adult mammalian cardiomyocytes successfully recorded for the first time on a high throughput automated patch clamp system
Source: Nanion Technologies
Industry
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Biohaven Sets New Course with $258 Million in Cash and Deep Pipeline to Advance Science for Patients
Source: Biohaven
Industry
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Jaguar Health Subsidiary Napo Pharmaceuticals Announces Activation by FDA of IND Application for NP-300 (Lechlemer)
Source: Jaguar Health
Industry
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FDA grants Orphan Drug Designation for NMD670 for the Treatment of Myasthenia Gravis
Source: NMD Pharma
Research
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TRPC6 Blocking Improves Muscle Function and Survival in Mice with Severe Duchenne Muscular Dystrophy
Source: Johns Hopkins Medicine
Researchers discovered that blocking the TRPC6 channel in genetically modified mice with severe or moderate Duchenne muscular dystrophy substantially improves their skeletal and cardiac muscle function, bone deformities and survival.
Industry
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Gate Neurosciences Emerges from Stealth with a Portfolio of Next-Generation Therapies for CNS Diseases
Source: Gate Neurosciences
Industry
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Alcon to Acquire Aerie Pharmaceuticals, Inc., Enhancing its Ophthalmic Pharmaceutical Portfolio
Source: Aerie Pharmaceuticals
Industry
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Aerie Pharmaceuticals Announces First Participant Dosed in the COMET-3 Study of its TRPM8 agonist AR-15512 for the Treatment of Dry Eye Disease
Source: Aerie Pharmaceuticals
Industry
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The SyncroPatch 384 from Nanion has been installed at the MBExC Cluster of Excellence at the University Medical Centre Göttingen
Source: Nanion Technologies
Research
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A New Mechanism Responsible for Controlling Auditory Sensitivity
Source: University of Colorado
cAMP and voltage modulate rat auditory mechanotransduction by decreasing the stiffness of gating springs.
Research
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New findings reveal how neurons build and maintain their capacity to communicate
Source: MIT
While the biosynthesis of the voltage-gated Ca2+ channels does not play a major role in regulating their abundance at presynaptic active zones, both trafficking and recycling at active zones are important regulatory steps.
Research
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Opening New Doors: First Synthetic Mechanosensitive Potassium Channel
Source: Tokyo Institute of Technology
Inspired by mechanosensitive potassium channels found in nature, researchers have developed the first synthetic mechanosensitive potassium channel.
Research
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Breaking the vicious itch-scratch cycle by targeting ‘miswired’ neurons
Source: Fierce Biotech
Researchers showed that the Piezo2 channels in Merkel cells are responsible for the itch triggered by mechanical stimulation in dry skin.
Research
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Researchers discovered novel light-gated potassium channel
Source: The University of Texas Health Science Center at Houston
Researcher have discovered two naturally occurring channelrhodopsins enabling optogenetic control of K+ gradients, which is promising for the study and potential treatment of potassium channelopathies such as epilepsy, Parkinson’s disease and long-QT syndrome and other cardiac arrhythmias.
Industry
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Metrion Biosciences appoints Dr Benedetta Montagnini as Head of European Business Development
Source: Metrion Biosciences
Industry
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Newron shows encouraging results for evenamide (Nav channel inhibitor) in patients with treatment-resistant schizophrenia
Source: Newron Pharmaceuticals
Industry
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Aerie Pharmaceuticals Announces First Participant Dosed in the Phase 3 Registrational COMET-2 Study of AR-15512 for the Treatment of Dry Eye Disease
Source: Aerie Pharmaceuticals
Research
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Research reveals surprising inactivation mechanism for a voltage-gated ion channel
Source: St. Jude Children’s Research Hospital
New findings elucidate mechanisms of closed-state inactivation and voltage-dependent activation of the KV4 channel.
Industry
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NMD Pharma expands its US presence with the creation of NMD Pharma US, Inc.
Source: NMD Pharma
Industry
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The SyncroPatch 384 from Nanion is installed at the FDA for cardiac safety pharmacology studies
Source: Nanion Technologies
Industry
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Bridge Biotherapeutics Enters into an Option-to-License Agreement with CellionBioMed to Develop BBT-301 for the Treatment of Multiple Fibrotic Diseases
Source: Bridge Biotherapeutics
Industry
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David Clapham joins Caraway Therapeutics as a scientific advisor
Source: Caraway Therapeutics
Research
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Gene therapy inspired by bacteria shows promise for cardiac conduction disorders
Source: Fierce Biotech
Scientists demonstrated that prokaryotic sodium channels can be directly, specifically, and stably expressed in cardiomyocytes through viral gene delivery to augment tissue excitability and conduction.
Industry
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Morphoceuticals Inc. Hails Successful Limb Regeneration in Adult Frogs
Source: Business Wire
Industry
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CalciMedica Initiates CARDEA-Plus: A Clinical Trial of Auxora™ in Patients with Critical COVID-19 Pneumonia
Source: CalciMedica
Industry
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Sophion introduced QPatch Compact – a new bench-top semi-automated patch clamp system
Source: Sophion Bioscience
Industry
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Metrion Biosciences and Bioqube Ventures collaborate to identify Kv1.3 inhibitors for autoimmune disorders
Source: Metrion Biosciences
Industry
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Metrion Biosciences expands ion channel drug discovery service capabilities and in-house expertise
Source: Metrion Biosciences
Industry
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Metrion Biosciences appoints Rory Curtis as Vice President US Commercial Operations
Source: Metrion Biosciences
Research
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A striking difference between neurons of humans and other mammals
Source: MIT
Human neurons have fewer ion channels compared to the neurons of other mammals.
Industry
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Metrion Biosciences expands into new headquarters to support continued growth
Source: Metrion Biosciences
Industry
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Metrion Biosciences appoints Nick Foster as Chief Commercial Officer and Head of Global Business Development
Source: Metrion Biosciences
Industry
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Saniona initiates Phase 1 clinical trial of SAN711 for the treatment of rare neuropathic disorders
Source: Saniona
Industry
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Sophion Bioscience and Genedata Announce New Genedata Ready-to-Run Partnership
Source: Sophion Bioscience
Industry
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Caraway Therapeutics and AbbVie join forces to develop novel TMEM175 modulators for Parkinson’s disease and other neurodegenerative disorders
Source: Caraway Therapeutics
Industry
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Metrion Biosciences appoints Mark Keogh as Non-Executive Director
Source: Metrion Biosciences
Industry
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Metrion Biosciences raises £2.7m and adds GLP cardiac safety services to the suite of ion channel drug discovery services
Source: Metrion Biosciences
Industry
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CalciMedica Raises $21 Million in Series D Financing to support the clinical development of CRAC channel inhibitors
Source: CalciMedica
Industry
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Soleno Therapeutics collaborates with Vanderbilt University to discover and develop novel KATP channel activators for the treatment of rare diseases
Source: Soleno Therapeutics
Industry
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Metrion Biosciences appoints John Montana as Non-Executive Director
Source: Metrion Biosciences
Industry
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Metrion Biosciences collaborates with Sosei Heptares to Explore Structure-based Drug Discovery Approaches to Ion Channels
Source: Metrion Biosciences
Research
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Chemists discover the structure of a key coronavirus protein
Source: MIT
An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity.
Research
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Outstanding ion channel scientists receive honorary awards
October 2020 has really become a month of awards for ion channel researchers.
Insights
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Is crowdfunding an option to finance your research?
Crowdfunding emerged as an interesting option of raising money for small research projects and it could be particularly interesting to early-stage scientists and students. Discover the platforms for crowdfunding scientific research in this article.
Bizarre
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What is an ion?
Outside of science, many people have a completely different idea of what an "ion" actually means.
Research
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Ardem Patapoutian and David Julius have won the 2020 Kavli Prize in Neuroscience
Source: The Kavli Prize
The Norwegian Academy of Science and Letters has decided to award the 2020 Kavli Prize in Neuroscience to David Julius and Ardem Patapoutian “for their transformative discovery of receptors for temperature and pressure.”
Industry
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Nanion Technologies and NEXEL partner to open a new reference demonstration laboratory in South Korea
Source: Nanion Technologies
Analytics
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Trends in ion channel paper authorship
This article shows how authors are distributed over ion channel papers (the number of authors per paper).
Analytics
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How many ion channel scientists are there?
How many ion channel scientists, labs, companies are there in the world? See the estimate in this article.
Analytics
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TOP ion channel-friendly journals
The choice of the journal for publishing your research is a strategic decision. This article will help you to chose the ion channel-friendly journal to publish your research in.
Analytics
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Ion channel journal trends
How many journals publish ion channel-related research? Do we need a lot of journals?
Fundamentals
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Extraordinary ordinary patch-clamp
The paper on patch-clamping by Erwin Neher and Bert Sakmann (1976) has been selected as 1 out of 10 extraordinary Nature papers.
Fundamentals
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Membrane transport
Every cell possesses a variety of sophisticated membrane transport systems allowing for control of the intracellular environment.
Fundamentals
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History of ion channels
Before the 1660s the Theory of Animal Spirits dominated thinking regarding the function of the nervous system. “Animal spirits” (originating in the brain) were believed to control movements of the body by flowing through the nerves into the muscles.
Analytics
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Ion channel publication trends
Here is the outlook of an ion channel research productivity expressed in the number of ion channel-related papers per year.
Fundamentals
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Nobel Prizes
The scientific community has recognized the crucial importance of ion channel research by four Nobel Prizes for the discoveries concerning the structure and function of ion channels.
Fundamentals
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Why we should care about ion channels
“… ion channels are the most important single class of proteins that exist in the human body or any body…” - Clay Armstrong
Research
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Cryo-EM Structure of the Cardiac Sodium Channel Nav1.5 Revealed
The high-resolution structure of the cardiac sodium channel gives detailed insights into voltage-dependent activation, ion selectivity, arrhythmia mechanisms, and antiarrhythmic drug action at the atomic level.
Research
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