Image by NomeVisualizzato from Pixabay

Research

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Source: Children's Hospital of Philadelphia

The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disorder.

Lille, France

Events

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This meeting will be dedicated to exploring ion channel regulation from molecular biophysics to physiology and clinical applications in cancer biology. Meeting will also include one ECS session: "Calcium signaling in cancer".

AnnaGrekaWebinar-2022 - Life Sciences Switzerland

Past Events

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Anna Greka leads a program focused on dissecting fundamental mechanisms of disrupted cellular homeostasis in genetically-defined kidney, metabolic and degenerative diseases...

Worldwide-Sodium-Channel-Seminars

Past Events

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The pharmacological activity of pain-causing toxins can provide critical insights into the molecular mechanisms underpinning sensory neuron function and pain...

urine test

Research

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Source: Aarhus University

Challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.

Careers

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Source: Metrion

Careers

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Source: Metrion Biosciences

Careers

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Source: jobRxiv

Careers

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Source: Nature careers

Careers

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Source: Nanion

Careers

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Source: Nanion

Metrion Biosciences

Past Events

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Many de novo missense mutations of SCN8A, the gene that encodes for Nav1.6, have been identified and patients have seizure onset between birth and 12 months of age...

Building

Events

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This symposium, the 7th in an ongoing series, will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.

sgp2023

Events

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This 2023 SGP Meeting will be focused on the topic of pain and will offer an excellent opportunity for participants to interact with leading scientists tackling impactful questions in the pain field, from the biophysical to behavioral level.

cancer cells

Research

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Source: Imperial College London

The high-throughout, cellular-resolution imaging data indicate that Vm fluctuates dynamically in subpopulations of highly aggressive breast cancer cell lines.

heart

Research

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Source: Weill Cornell Medicine

Anionic lipids unlock the gates of select ion channels in the pacemaker family

Research

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Source: University College London

UCL researchers developed a gene therapy strategy that self-selects pathologically overactive neurons and down-regulates their excitability via controlled expression of Kv1.1.

cancer-cells

Research

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Source: Johns Hopkins Medicine

Elevated viscosity counterintuitively increases the motility of various cell types in a TRPV4-dependent manner.

sleep

Research

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Source: Johns Hopkins Medicine

TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.

Events

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Industry

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Source: Sophion Bioscience

lab mouse - Image by Tibor Janosi Mozes from Pixabay

Research

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Source: Johns Hopkins Medicine

Researchers discovered that blocking the TRPC6 channel in genetically modified mice with severe or moderate Duchenne muscular dystrophy substantially improves their skeletal and cardiac muscle function, bone deformities and survival.

A girl listening to music - Photo by Tirachard Kumtanom on Pexels

Research

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Source: University of Colorado

cAMP and voltage modulate rat auditory mechanotransduction by decreasing the stiffness of gating springs.

car park

Research

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Source: MIT

While the biosynthesis of the voltage-gated Ca2+ channels does not play a major role in regulating their abundance at presynaptic active zones, both trafficking and recycling at active zones are important regulatory steps.

chemist - Image by Michal Jarmoluk from Pixabay

Research

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Source: Tokyo Institute of Technology

Inspired by mechanosensitive potassium channels found in nature, researchers have developed the first synthetic mechanosensitive potassium channel.

Cat, itch - Photo by Fox on Pexels

Research

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Source: Fierce Biotech

Researchers showed that the Piezo2 channels in Merkel cells are responsible for the itch triggered by mechanical stimulation in dry skin.

flashlight

Research

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Source: The University of Texas Health Science Center at Houston

Researcher have discovered two naturally occurring channelrhodopsins enabling optogenetic control of K+ gradients, which is promising for the study and potential treatment of potassium channelopathies such as epilepsy, Parkinson’s disease and long-QT syndrome and other cardiac arrhythmias.

Kv4

Research

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Source: St. Jude Children’s Research Hospital

New findings elucidate mechanisms of closed-state inactivation and voltage-dependent activation of the KV4 channel.

Caraway Therapeutics

Industry

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Source: Caraway Therapeutics

money

Industry

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Source: NMD Pharma

heart - Photo by Robina Weermeijer on Unsplash

Research

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Source: Fierce Biotech

Scientists demonstrated that prokaryotic sodium channels can be directly, specifically, and stably expressed in cardiomyocytes through viral gene delivery to augment tissue excitability and conduction.

Icagen - neuron

Industry

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Source: Ligand Pharmaceuticals

neurons

Research

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Source: MIT

Human neurons have fewer ion channels compared to the neurons of other mammals.

Metrion Biosciences

Industry

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Source: Metrion Biosciences

Nanion Technologies

Industry

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Source: Nanion Technologies

businessman

Industry

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Source: Metrion Biosciences

businessman - Photo by Adetola Afolabi on Unsplash

Industry

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Source: Metrion Biosciences

coronavirus - Photo by Fusion Medical Animation on Unsplash

Research

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Source: MIT

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity.

Trophies

Research

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October 2020 has really become a month of awards for ion channel researchers.

crowd

Insights

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Crowdfunding emerged as an interesting option of raising money for small research projects and it could be particularly interesting to early-stage scientists and students. Discover the platforms for crowdfunding scientific research in this article.

pipe

Bizarre

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Discover different meaning of the word "channel" here.

ion road sign

Bizarre

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Outside of science, many people have a completely different idea of what an "ion" actually means.

Ardem Patapoutian and David Julius

Research

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Source: The Kavli Prize

The Norwegian Academy of Science and Letters has decided to award the 2020 Kavli Prize in Neuroscience to David Julius and Ardem Patapoutian “for their transformative discovery of receptors for temperature and pressure.”

numbers

Analytics

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This article shows how authors are distributed over ion channel papers (the number of authors per paper).

ion channel scientists

Analytics

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How many ion channel scientists, labs, companies are there in the world? See the estimate in this article.

journals

Analytics

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The choice of the journal for publishing your research is a strategic decision. This article will help you to chose the ion channel-friendly journal to publish your research in.

journal_trends_featured

Analytics

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How many journals publish ion channel-related research? Do we need a lot of journals?

library

Uncategorized

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electrical signals

Infographics

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tulips

Fundamentals

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The paper on patch-clamping by Erwin Neher and Bert Sakmann (1976) has been selected as 1 out of 10 extraordinary Nature papers.

highway with cars

Fundamentals

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Every cell possesses a variety of sophisticated membrane transport systems allowing for control of the intracellular environment.

Galvani experiment

Fundamentals

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Before the 1660s the Theory of Animal Spirits dominated thinking regarding the function of the nervous system. “Animal spirits” (originating in the brain) were believed to control movements of the body by flowing through the nerves into the muscles.

membrane transport

Infographics

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lipid membrane permeability

Infographics

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graph

Analytics

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Here is the outlook of an ion channel research productivity expressed in the number of ion channel-related papers per year.

Alfred Nobel

Fundamentals

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The scientific community has recognized the crucial importance of ion channel research by four Nobel Prizes for the discoveries concerning the structure and function of ion channels.

ion channel surface

Fundamentals

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See how different scientists define ion channels.

a hand with lightnings inside

Fundamentals

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“… ion channels are the most important single class of proteins that exist in the human body or any body…” - Clay Armstrong

ion channel structure

Research

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The high-resolution structure of the cardiac sodium channel gives detailed insights into voltage-dependent activation, ion selectivity, arrhythmia mechanisms, and antiarrhythmic drug action at the atomic level.

metallic keys

Research

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The patch-clamp technique has been described by Nature journal as “a breakthrough method that became vital to neuroscience”.