Latest
Industry news
Industry
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Metrion Biosciences invests in new High Throughput Screening capability and expanded facilities
Source: Metrion Biosciences
Industry
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Gate Neurosciences Doses First Subject in a Translational EEG Biomarker Study of Apimostinel, a Rapid-Acting Treatment for Acute Depressive Disorders
Source: Gate Neurosciences
Industry
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Kriya acquires Redpin Therapeutics, adding its ion channel-based chemogenetics platform and pipeline to gene therapy engine
Source: Kriya Therapeutics
Research highlights
Research
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Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy
Source: Children’s Hospital of Philadelphia
The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disorder.
Research
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New test can help patients with cystic fibrosis
Source: Aarhus University
Challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.
Research
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Scientists uncover potential “electrical language” of breast cancer cells
Source: Imperial College London
The high-throughout, cellular-resolution imaging data indicate that Vm fluctuates dynamically in subpopulations of highly aggressive breast cancer cell lines.
Research
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Pacemaker Channel Discovery Could Lead to Better Heart Drugs
Source: Weill Cornell Medicine
Anionic lipids unlock the gates of select ion channels in the pacemaker family
Upcoming Events
Meeting
Ion channels and cancer meeting 2022
December 6-8, 2022
Abstract submission deadline: November 15, 2023
Lille, France
Webinar
Voltage-gated sodium channels and cancer – Dr William Brackenbury, University of York
December 13, 2022
Organized by: Angelika Lampert and Hugues Abriel
Annual Meeting
Biophysical Society Annual Meeting
February 18-22, 2023
Abstract submission deadline: January 5, 2023
San Diego, CA, USA
Featured Recurring Events
Webinar series
Next webinar: 13/12/2022
Featured
Worldwide Sodium Channel Seminars
Lecture series bringing together sodium channel researchers worldwide.
WEBINAR SERIES
Next webinar: 14/12/2022
Featured
Ion Channels & Transporters in Immunity (ICTI) Seminar Series
A virtual platform for the exchange of ideas and discussion on topics related to ion channels and transporters in immunity.
Webinar series
Next webinar: 2023
Featured
Metrion’s “Ion Channels in Drug Discovery” webinars
Webinar series on all things ion channels.
Symposium
Next symposium: 2023
Featured
Sophion’s Ion Channel Modulation Symposium
A high-level ion channel drug discovery symposium bringing together researchers from academia and industry.
Careers
Careers
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Industry
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Featured
Research Technician
Metrion Biosciences, Cambridge, UK
Source: Metrion
Careers
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Industry
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Featured
Scientist, Drug Discovery (Electrophysiology)
Metrion Biosciences, Cambridge, UK
Source: Metrion Biosciences
Careers
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Academia
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Postdoctoral positions – Minor Lab @ UCSF
UCSF Cardiovascular Research Institute, San Francisco, USA
Source: jobRxiv
Careers
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Academia
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Postdoctoral Associate
Weill Cornell Medicine, New York, NY, USA
Source: Nature careers
Careers
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Industry
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Featured
Field Application Scientist
Nanion Technologies, Livingston, New Jersey, USA
Source: Nanion
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Industry
Industry
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Sophion Bioscience and Sussex Drug Discovery Centre strengthen collaboration
Source: Sophion Bioscience
Industry
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Relmada Therapeutics reported a Phase III fail for its lead NMDAR blocker, REL-1017, in major depressive disorder
Source: Relmada Therapeutics
Industry
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Adult mammalian cardiomyocytes successfully recorded for the first time on a high throughput automated patch clamp system
Source: Nanion Technologies
Industry
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Biohaven Sets New Course with $258 Million in Cash and Deep Pipeline to Advance Science for Patients
Source: Biohaven
Industry
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Jaguar Health Subsidiary Napo Pharmaceuticals Announces Activation by FDA of IND Application for NP-300 (Lechlemer)
Source: Jaguar Health
Industry
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FDA grants Orphan Drug Designation for NMD670 for the Treatment of Myasthenia Gravis
Source: NMD Pharma
Industry
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Gate Neurosciences Emerges from Stealth with a Portfolio of Next-Generation Therapies for CNS Diseases
Source: Gate Neurosciences
Industry
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Alcon to Acquire Aerie Pharmaceuticals, Inc., Enhancing its Ophthalmic Pharmaceutical Portfolio
Source: Aerie Pharmaceuticals
DIRECTORIES
In the Spotlight
Metrion Biosciences is a UK-based pre-clinical CRO providing highly skilled electrophysiology screening services to support client medicinal chemistry optimisation programmes, CiPA-compliant cardiac safety profiling assays, neuroscience assays and translational assays.
RESEARCH
Research highlights
Research
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Gene therapy targeting overactive brain cells could treat neurological disorders
Source: University College London
UCL researchers developed a gene therapy strategy that self-selects pathologically overactive neurons and down-regulates their excitability via controlled expression of Kv1.1.
Research
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Extracellular fluid viscosity enhances cell migration and cancer dissemination
Source: Johns Hopkins Medicine
Elevated viscosity counterintuitively increases the motility of various cell types in a TRPV4-dependent manner.
Latest Articles PUBMED
Latest Preprints Biorxiv
- Identification of a sensory neuron Cav2.3 inhibitor within a new superfamily of macro-conotoxins
- Deletion of TRPC6, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells
- Genetic pathways regulating the longitudinal acquisition of cocaine self administration in mice
- KATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine Induced Hypersensitivity, and Precipitated Withdrawal in Mice
- Immediate reuse of patch-clamp pipettes with ultrasonic cleaning
- The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons
- A Drosophila Wolfram Syndrome 1 (WFS1) homologue synergises with the intracellular Ca2+ release channel, IP3R to affect mitochondrial morphology and function
- Characterization of TMEM43 as a novel ion channel
- Ion channel model reduction using manifold boundaries
- Emergence of ion-channel mediated electrical oscillations in E. coli biofilms
Ion channel research in numbers
Interviews
Latest PATENTS ESPACENET
Ongoing CLINICAL TRIALS
Fundamentals
Fundamentals
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Why we should care about ion channels
“… ion channels are the most important single class of proteins that exist in the human body or any body…” – Clay Armstrong
Fundamentals
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History of ion channels
Before the 1660s the Theory of Animal Spirits dominated thinking regarding the function of the nervous system. “Animal spirits” (originating in the brain) were believed to control movements of the body by flowing through the nerves into the muscles.
