Latest
Industry news
Industry
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Praxis Precision Medicines Announces Positive Topline Results from PRAX-628 Phase 1 Study
Source: Praxis Precision Medicines
Industry
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Veneno Technologies Announces Joint Research Agreement with Sumitomo Pharma
Source: Veneno Technologies
Industry
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Maxion Therapeutics awarded £2 million Innovate UK funding to develop ion channel antibodies for “hard-to-treat” autoimmune diseases
Source: Maxion Therapeutics
Industry
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BELLUS Health Announces Positive Results from its Phase 1 Camlipixant Study
Source: BELLUS Health
Research highlights
Research
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Mechanical forces caused by foetal movements drive skeletal development
Source: University College Dublin
New study identifies the TRPV4 channel as playing a key role in translating mechanical signals from a baby’s movement in the womb to healthy development of the skeleton.
Research
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Treating gut pain via a Nobel prize-winning receptor
Source: Flinders University
Targeting Piezo2 could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome.
Research
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Researchers developed a method to target specific neurons and change their excitability with light for long periods of time
Source: Harvard John A. Paulson School of Engineering and Applied Sciences
A new method for modulating neural activity using optogenetic polymerization and assembly of electroactive polymers on specified cellular membranes.
Research
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Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy
Source: Children’s Hospital of Philadelphia
The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disorder.
Upcoming Events
Course
Ion Channels in Synaptic and Neural Circuit Physiology
June 6 – 25, 2023
Application Deadline: March 1, 2023
Cold Spring Harbor, USA
Conference
Cure CLCN4 Scientific Conference 2023
June 16-17, 2023
Registration deadline: June 1, 2023
London, UK
Conference
The Calcium and Cell Function Conference
June 25 – 30, 2023
Registration deadline: June 21, 2023
Malahide, Ireland
Featured Recurring Events
Webinar series
Next webinar: 27/06/2023
Featured
Worldwide Sodium Channel Seminars
Lecture series bringing together sodium channel researchers worldwide.
WEBINAR SERIES
Next webinar: 21/06/2023
Featured
Ion Channels & Transporters in Immunity (ICTI) Seminar Series
A virtual platform for the exchange of ideas and discussion on topics related to ion channels and transporters in immunity.
virtual seminar series
Next seminar: 06/06/2023
Featured
EpIC Seminars
Monthly virtual seminar series showcasing some of the most exciting recent research in the field of Electrophysiology and Ion Channels
Symposium
Next symposium: 21 – 22 June 2023
Featured
Sophion’s Ion Channel Modulation Symposium
A high-level ion channel drug discovery symposium bringing together researchers from academia and industry.
Expert opinions
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Industry
Industry
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Axalbion to Present Promising Phase 2 Clinical Data in Chronic Cough with AX-8, a Novel TRPM8 Agonist
Source: Axalbion
Industry
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NRx Pharmaceuticals Announces Close of $2.9 Million Registered Direct Offering
NRx Pharmaceuticals
Industry
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QurAlis Closes $88 Million Series B Financing to Advance Precision Medicines for Neurodegenerative Diseases
Source: QurAlis
Industry
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Praxis Announces Topline Results from the Essential1 Study of Ulixacaltamide for the Treatment of Essential Tremor
Source: Praxis Precision Medicines
Industry
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Maxion Therapeutics raises $16 million to develop novel biologics targeting ion channels and GPCRs
Source: Maxion Therapeutics
Industry
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FDA Accepts Filing of New Drug Application and Grants Priority Review of Zuranolone
Source: Sage Therapeutics
Industry
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Karuna Therapeutics to obtain global development, manufacturing, and commercialization rights to Goldfinch Bio’s investigational TRPC4/5 channel candidates.
Source: Karuna Therapeutics
Industry
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Sygnature Discovery completes acquisition of SB Drug Discovery to further strengthen its market-leading capabilities
Source: SB Drug Discovery
RESEARCH
Research highlights
Research
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New test can help patients with cystic fibrosis
Source: Aarhus University
Challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.
Research
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Scientists uncover potential “electrical language” of breast cancer cells
Source: Imperial College London
The high-throughout, cellular-resolution imaging data indicate that Vm fluctuates dynamically in subpopulations of highly aggressive breast cancer cell lines.
Latest Articles PUBMED
Latest Preprints Biorxiv
- Identification of a sensory neuron Cav2.3 inhibitor within a new superfamily of macro-conotoxins
- Deletion of TRPC6, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells
- Genetic pathways regulating the longitudinal acquisition of cocaine self administration in mice
- KATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine Induced Hypersensitivity, and Precipitated Withdrawal in Mice
- Immediate reuse of patch-clamp pipettes with ultrasonic cleaning
- The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons
- A Drosophila Wolfram Syndrome 1 (WFS1) homologue synergises with the intracellular Ca2+ release channel, IP3R to affect mitochondrial morphology and function
- Characterization of TMEM43 as a novel ion channel
- Ion channel model reduction using manifold boundaries
- Emergence of ion-channel mediated electrical oscillations in E. coli biofilms
Ion channel research in numbers
Interviews
Latest PATENTS ESPACENET
Ongoing CLINICAL TRIALS
Fundamentals
Fundamentals
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Why we should care about ion channels
“… ion channels are the most important single class of proteins that exist in the human body or any body…” – Clay Armstrong
Fundamentals
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History of ion channels
Before the 1660s the Theory of Animal Spirits dominated thinking regarding the function of the nervous system. “Animal spirits” (originating in the brain) were believed to control movements of the body by flowing through the nerves into the muscles.
