Latest
Industry news
Industry
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Axalbion to Present Promising Phase 2 Clinical Data in Chronic Cough with AX-8, a Novel TRPM8 Agonist
Source: Axalbion
Industry
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NRx Pharmaceuticals Announces Close of $2.9 Million Registered Direct Offering
NRx Pharmaceuticals
Industry
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QurAlis Closes $88 Million Series B Financing to Advance Precision Medicines for Neurodegenerative Diseases
Source: QurAlis
Industry
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Praxis Announces Topline Results from the Essential1 Study of Ulixacaltamide for the Treatment of Essential Tremor
Source: Praxis Precision Medicines
Research highlights
Research
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Mechanical forces caused by foetal movements drive skeletal development
Source: University College Dublin
New study identifies the TRPV4 channel as playing a key role in translating mechanical signals from a baby’s movement in the womb to healthy development of the skeleton.
Research
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Treating gut pain via a Nobel prize-winning receptor
Source: Flinders University
Targeting Piezo2 could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome.
Research
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Researchers developed a method to target specific neurons and change their excitability with light for long periods of time
Source: Harvard John A. Paulson School of Engineering and Applied Sciences
A new method for modulating neural activity using optogenetic polymerization and assembly of electroactive polymers on specified cellular membranes.
Research
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Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy
Source: Children’s Hospital of Philadelphia
The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disorder.
Upcoming Events
Meeting
Cambridge Ion Channel Forum
May 10, 2023
Babraham, Cambridge, UK
Organized by: Metrion Biosciences and AstraZeneca
Course
Ion Channels in Synaptic and Neural Circuit Physiology
June 6 – 25, 2023
Application Deadline: March 1, 2023
Cold Spring Harbor, USA
Featured Recurring Events
Webinar series
Next webinar: 28/03/2023
Featured
Worldwide Sodium Channel Seminars
Lecture series bringing together sodium channel researchers worldwide.
WEBINAR SERIES
Next webinar: 19/04/2023
Featured
Ion Channels & Transporters in Immunity (ICTI) Seminar Series
A virtual platform for the exchange of ideas and discussion on topics related to ion channels and transporters in immunity.
Webinar series
Next webinar: 2023
Featured
Metrion’s “Ion Channels in Drug Discovery” webinars
Webinar series on all things ion channels.
Symposium
Next symposium: 21 – 22 June 2023
Featured
Sophion’s Ion Channel Modulation Symposium
A high-level ion channel drug discovery symposium bringing together researchers from academia and industry.
Expert opinions
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Industry
Industry
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Maxion Therapeutics raises $16 million to develop novel biologics targeting ion channels and GPCRs
Source: Maxion Therapeutics
Industry
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FDA Accepts Filing of New Drug Application and Grants Priority Review of Zuranolone
Source: Sage Therapeutics
Industry
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Karuna Therapeutics to obtain global development, manufacturing, and commercialization rights to Goldfinch Bio’s investigational TRPC4/5 channel candidates.
Source: Karuna Therapeutics
Industry
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Sygnature Discovery completes acquisition of SB Drug Discovery to further strengthen its market-leading capabilities
Source: SB Drug Discovery
Industry
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Catalyst Pharmaceuticals to Acquire U.S. Commercial Rights to FYCOMPA® (Perampanel) CIII From Eisai Co., Ltd
Source: Catalyst Pharmaceuticals
Industry
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Gilgamesh Pharmaceuticals Raises $39 Million Series B to Advance Mental Health Treatments
Source: PRNewswire
Industry
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Sionna Therapeutics Announces IND Clearance and Phase 1 Initiation for SION-638 in Cystic Fibrosis
Source: Sionna Therapeutics
Industry
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Bionomics’ Social Anxiety Disorder Lead Candidate Failed to Hit the Primary Endpoint in Phase 2 Study
Source: Bionomics
Industry
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Praxis Precision Medicines partners with UCB to discover potential treatments for KCNT1-related epilepsies
Source: Praxis Precision Medicines
RESEARCH
Research highlights
Research
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New test can help patients with cystic fibrosis
Source: Aarhus University
Challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.
Research
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Scientists uncover potential “electrical language” of breast cancer cells
Source: Imperial College London
The high-throughout, cellular-resolution imaging data indicate that Vm fluctuates dynamically in subpopulations of highly aggressive breast cancer cell lines.
Latest Articles PUBMED
Latest Preprints Biorxiv
- Identification of a sensory neuron Cav2.3 inhibitor within a new superfamily of macro-conotoxins
- Deletion of TRPC6, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells
- Genetic pathways regulating the longitudinal acquisition of cocaine self administration in mice
- KATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine Induced Hypersensitivity, and Precipitated Withdrawal in Mice
- Immediate reuse of patch-clamp pipettes with ultrasonic cleaning
- The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons
- A Drosophila Wolfram Syndrome 1 (WFS1) homologue synergises with the intracellular Ca2+ release channel, IP3R to affect mitochondrial morphology and function
- Characterization of TMEM43 as a novel ion channel
- Ion channel model reduction using manifold boundaries
- Emergence of ion-channel mediated electrical oscillations in E. coli biofilms
Ion channel research in numbers
Interviews
Latest PATENTS ESPACENET
Ongoing CLINICAL TRIALS
Fundamentals
Fundamentals
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Why we should care about ion channels
“… ion channels are the most important single class of proteins that exist in the human body or any body…” – Clay Armstrong
Fundamentals
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History of ion channels
Before the 1660s the Theory of Animal Spirits dominated thinking regarding the function of the nervous system. “Animal spirits” (originating in the brain) were believed to control movements of the body by flowing through the nerves into the muscles.
